PDBsum entry 6zqw

Virus

PDB id: 6zqw

Contents

Protein chains

504 a.a.

101 a.a.

50 a.a.

Ligands

NAG ×3

PDB id:

6zqw

Name:

Virus

Title:

Cryo-em structure of immature spondweni virus

Structure:

Genome polyprotein. Chain: a, d, g. Prm. Chain: b, e, h, i, f, c. Synonym: prm

Source:

Spondweni virus. Organism_taxid: 64318. Organism_taxid: 64318

Authors:

M.Renner,W.Dejnirattisai,L.Carrique,I.Serna Martin,D.Karia,S.L.Ilca, S.F.Ho,A.Kotecha,J.R.Keown,J.Mongkolsapaya,G.R.Screaton,J.M.Grimes

Key ref:

M.Renner et al. A high resolution view of an adolescent flavivirus. To be published, . PubMed id: 33623019

Date:

10-Jul-20 Release date: 20-Jan-21

Protein chains

C8XPB6  (C8XPB6_9FLAV) -  Genome polyprotein from Spondweni virus

Seq: 3429 a.a.

Struc: 504 a.a.*

Protein chains

C8XPB6  (C8XPB6_9FLAV) -  Genome polyprotein from Spondweni virus

Seq: 3429 a.a.

Struc: 101 a.a.

Protein chains

C8XPB6  (C8XPB6_9FLAV) -  Genome polyprotein from Spondweni virus

Seq: 3429 a.a.

Struc: 50 a.a.

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class 1: Chains A, B, D, E, G, H, I, F, C: E.C.3.4.21.91 - flavivirin.
• Reaction: Selective hydrolysis of Xaa-Xaa-|-Xbb bonds in which each of the Xaa can be either Arg or Lys and Xbb can be either Ser or Ala.
• Enzyme class 2: Chains A, B, D, E, G, H, I, F, C: E.C.3.6.1.15 - nucleoside-triphosphate phosphatase.
• Reaction: a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H⁺
• Enzyme class 3: Chains A, B, D, E, G, H, I, F, C: E.C.3.6.4.13 - Rna helicase.
• Reaction: ATP + H2O = ADP + phosphate + H⁺

ATP + H2O = ADP (Bound ligand (Het Group name = NAG) matches with 41.38% similarity) + phosphate + H(+)

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site