PDBsum entry 6xfs

Hydrolase/hydrolase inhibitor

PDB id: 6xfs

Contents

Protein chains

357 a.a.

Ligands

TBE ×4

EDO ×4

PGE ×2

PEG

Waters ×83

PDB id:

6xfs

Name:

Hydrolase/hydrolase inhibitor

Title:

Class c beta-lactamase from escherichia coli in complex with tazobactam

Structure:

Beta-lactamase. Chain: a, b, c, d. Engineered: yes

Source:

Escherichia coli. Organism_taxid: 562. Gene: bla(ampc-ec31), blaec. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

2.70Å R-factor: 0.191 R-free: 0.249

Authors:

C.Chang,N.Maltseva,M.Endres,A.Joachimiak,Center For Structural Genomics Of Infectious Diseases (Csgid)

Key ref:

C.Chang et al. Class c beta-Lactamase from escherichia coli in compl tazobactam. To be published, .

Date:

16-Jun-20 Release date: 15-Jul-20

Supersedes:

6wa7

Protein chains

P00811  (AMPC_ECOLI) -  Beta-lactamase from Escherichia coli (strain K12)

Seq: 377 a.a.

Struc: 357 a.a.*

* PDB and UniProt seqs differ at 5 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)