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PDBsum entry 6v8c
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PDB id:
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Transferase
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Title:
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Design, synthesis, and mechanism of fluorine-substituted cyclohexene analogues of gama-aminobutyric acid (gaba) as selective ornithine aminotransferase inactivators
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Structure:
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Ornithine aminotransferase, mitochondrial. Chain: a, b, c. Synonym: ornithine delta-aminotransferase,ornithine--oxo-acid aminotransferase. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: oat. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.90Å
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R-factor:
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0.240
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R-free:
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0.268
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Authors:
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W.Zhu,P.T.Doubleday,D.S.Catlin,P.Weerawarna,A.Butrin,S.Shen, N.L.Kelleher,D.Liu,R.B.Silverman
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Key ref:
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W.Zhu
et al.
Design, Synthesis, And mechanism of fluorine-Substitu cyclohexene analogues of gama-Aminobutyric acid (gaba selective ornithine aminotransferase inactivators.
To be published,
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Date:
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10-Dec-19
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Release date:
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16-Dec-20
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PROCHECK
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Headers
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References
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P04181
(OAT_HUMAN) -
Ornithine aminotransferase, mitochondrial from Homo sapiens
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Seq:
Struc:
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439 a.a.
404 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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Enzyme class:
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E.C.2.6.1.13
- ornithine aminotransferase.
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Reaction:
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a 2-oxocarboxylate + L-ornithine = L-glutamate 5-semialdehyde + an L-alpha-amino acid
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2-oxocarboxylate
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+
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L-ornithine
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=
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L-glutamate 5-semialdehyde
Bound ligand (Het Group name = )
matches with 58.33% similarity
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+
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L-alpha-amino acid
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Cofactor:
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Pyridoxal 5'-phosphate
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Pyridoxal 5'-phosphate
Bound ligand (Het Group name =
PLP)
matches with 93.75% similarity
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
