PDBsum entry 6tyk

Oxidoreductase

PDB id: 6tyk

Contents

Protein chains

185 a.a.

Ligands

FMN ×2

IYR ×3

Metals

_CL ×7

Waters ×342

PDB id:

6tyk

Name:

Oxidoreductase

Title:

Crystal structure of iodotyrosine deiodinase (iyd) in the semiquinone form bound to fmn and 3-iodo-l-tyrosine

Structure:

Iodotyrosine deiodinase. Chain: a, b. Synonym: iyd. Engineered: yes

Source:

Thermotoga neapolitana (strain atcc 49049 / dsm 4359 / ns-e). Organism_taxid: 309803. Strain: atcc 49049 / dsm 4359 / ns-e. Gene: ctn_0569. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.35Å R-factor: 0.160 R-free: 0.194

Authors:

Z.Sun,J.M.Kavran,S.E.Rokita

Key ref:

Z.Sun et al. Structure of tn iyd bound in the semiquinone form bou fmn and 3-Iodo-L-Tyrosine. To be published, .

Date:

09-Aug-19 Release date: 07-Apr-21

Protein chains

B9K712  (IYD_THENN) -  Iodotyrosine deiodinase from Thermotoga neapolitana (strain ATCC 49049 / DSM 4359 / NBRC 107923 / NS-E)

Seq: 186 a.a.

Struc: 185 a.a.

Enzyme reactions

• Enzyme class: E.C.1.21.1.1 - iodotyrosine deiodinase.
• Reaction: 2 iodide + L-tyrosine + 2 NADP⁺ = 3,5-diiodo-L-tyrosine + 2 NADPH + H⁺

2 × iodide + L-tyrosine + 2 × NADP(+) = 3,5-diiodo-L-tyrosine (Bound ligand (Het Group name = IYR) matches with 93.33% similarity) + 2 × NADPH + H(+)

• Cofactor: FMN

FMN (Bound ligand (Het Group name = FMN) corresponds exactly)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site