PDBsum entry 6ibm

Hydrolase

PDB id: 6ibm

Contents

Protein chains

390 a.a.

Ligands

NAG-NAG-BMA ×3

NAG-NAG ×2

NAG-NAG-BMA-MAN-MAN-MAN

PEG ×2

ACT ×4

SO4 ×6

HF8 ×2

EDO ×18

Waters ×272

PDB id:

6ibm

Name:

Hydrolase

Title:

Crystal structure of human alpha-galactosidase a in complex with alpha-galactose configured cyclosulfate me776

Structure:

Alpha-galactosidase a. Chain: a, b. Synonym: alpha-d-galactosidase a,alpha-d-galactoside galactohydrolase,melibiase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gla. Expressed in: cricetulus griseus. Expression_system_taxid: 10029

Resolution:

2.07Å R-factor: 0.183 R-free: 0.242

Authors:

R.J.Rowland,L.Wu,G.J.Davies

Key ref:

M.Artola et al. Alpha-D-Gal-Cyclophellitol cyclosulfamidate is a mich complex analog that stabilizes therapeutic lysosomal alpha-Galactosidase a in fabry disease. Chem sci, .

Date:

30-Nov-18 Release date: 09-Oct-19

Protein chains

P06280  (AGAL_HUMAN) -  Alpha-galactosidase A from Homo sapiens

Seq: 429 a.a.

Struc: 390 a.a.

Enzyme reactions

• Enzyme class: E.C.3.2.1.22 - alpha-galactosidase.
• Reaction: Melibiose + H₂O = galactose + glucose
• Cofactor: Mg(2+); NAD(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site