PDBsum entry 6n6t

Hydrolase

PDB id: 6n6t

Contents

Protein chain

232 a.a.

Ligands

FLC

Waters ×262

PDB id:

6n6t

Name:

Hydrolase

Title:

Oxa-23 mutant f110a/m221a low ph form

Structure:

Beta-lactamase oxa23. Chain: a. Fragment: unp residues 31-273. Synonym: carbapenem-hydrolyzing class d beta-lactamase oxa-23, carbapenemase oxa-23,class d beta-lactamase,oxa-23,oxa-23 carbapenemase,oxa-23 class d beta-lactamase,oxa23 carbapenemase,class d beta-lactamase oxa-23. Engineered: yes. Mutation: yes

Source:

Acinetobacter baumannii. Organism_taxid: 470. Gene: ari-1, bla(oxa-23), bla-oxa-23, bla-oxa-23, bla_1, bla_2, bla_3, blaoxa, blaoxa-23, blaoxa23, oxa-23, oxa-23, oxa23, a7m90_19440, ab719_18095, abuw_0563, aze33_05050, aze33_05100, aze33_05150, aze33_05250, c7g90_19950, cas83_19595, cbe85_20255, cbi29_04474, cej63_03230, dv997_16620, dva79_19285, ix87_16825, ix87_21860, lv38_03424, ng19_0098, samea104305208_04008, samea104305242_04084, samea104305271_04290, samea104305299_06196,

Resolution:

1.25Å R-factor: 0.156 R-free: 0.180

Authors:

C.A.Smith,S.B.Vakulenko

Key ref:

n.k.stewart et al. (2018). Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases. Antimicrob. Agents Chemother., 0, . PubMed id: 30530607

Date:

27-Nov-18 Release date: 19-Dec-18

Protein chain

Q9L4P2  (BLO23_ACIBA) -  Beta-lactamase OXA-23 from Acinetobacter baumannii

Seq: 273 a.a.

Struc: 232 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)

Antimicrob. Agents Chemother. 0: (2018)

PubMed id: 30530607

Role of the Hydrophobic Bridge in the Carbapenemase Activity of Class D beta-Lactamases.

n.k.stewart, c.a.smith, n.t.antunes, m.toth, s.b.vakulenk.

ABSTRACT

No abstract given.