PDBsum entry 5lof

Apoptosis/inhibitor

PDB id: 5lof

Contents

Protein chain

514 a.a.

Ligands

GLC-GLC

70R

Waters ×183

PDB id:

5lof

Name:

Apoptosis/inhibitor

Title:

Crystal structure of the mbp-mcl1 complex with highly selective and potent inhibitor of mcl1

Structure:

Maltose-binding periplasmic protein,induced myeloid leukemia cell differentiation protein mcl-1. Chain: a. Synonym: mbp,mmbp,maltodextrin-binding protein,bcl-2-like protein 3, bcl2-l-3,bcl-2-related protein eat/mcl1,mcl1/eat. Engineered: yes. Mutation: yes

Source:

Escherichia coli o157:h7, homo sapiens. Human. Organism_taxid: 83334, 9606. Gene: male, z5632, ecs5017, mcl1, bcl2l3. Expressed in: escherichia coli. Expression_system_taxid: 511693. Expression_system_variant: plyss

Resolution:

2.20Å R-factor: 0.184 R-free: 0.235

Authors:

P.Dokurno,A.Kotschy,Z.Szlavik,J.Murray,J.Davidson,M.Csekei,A.Paczal, Z.Szabo,S.Sipos,G.Radics,A.Proszenyak,B.Balint,L.Ondi,G.Blasko, A.Robertson,A.Surgenor,I.Chen,N.Matassova,J.Smith,C.Pedder,C.Graham, O.Geneste

Key ref:

A.Kotschy et al. (2016). The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models. Nature, 538, 477-482. PubMed id: 27760111 DOI: 10.1038/nature19830

Date:

09-Aug-16 Release date: 26-Oct-16

Protein chain

P0AEY0  (MALE_ECO57) -  Maltose/maltodextrin-binding periplasmic protein from Escherichia coli O157:H7

Seq: 396 a.a.

Struc: 514 a.a.*

Protein chain

Q07820  (MCL1_HUMAN) -  Induced myeloid leukemia cell differentiation protein Mcl-1 from Homo sapiens

Seq: 350 a.a.

Struc: 514 a.a.*

* PDB and UniProt seqs differ at 165 residue positions (black crosses)

DOI no: 10.1038/nature19830

Nature 538:477-482 (2016)

PubMed id: 27760111

The MCL1 inhibitor S63845 is tolerable and effective in diverse cancer models.

A.Kotschy, Z.Szlavik, J.Murray, J.Davidson, A.L.Maragno, G.Le Toumelin-Braizat, M.Chanrion, G.L.Kelly, J.N.Gong, D.M.Moujalled, A.Bruno, M.Csekei, A.Paczal, Z.B.Szabo, S.Sipos, G.Radics, A.Proszenyak, B.Balint, L.Ondi, G.Blasko, A.Robertson, A.Surgenor, P.Dokurno, I.Chen, N.Matassova, J.Smith, C.Pedder, C.Graham, A.Studeny, G.Lysiak-Auvity, A.M.Girard, F.Gravé, D.Segal, C.D.Riffkin, G.Pomilio, L.C.Galbraith, B.J.Aubrey, M.S.Brennan, M.J.Herold, C.Chang, G.Guasconi, N.Cauquil, F.Melchiore, N.Guigal-Stephan, B.Lockhart, F.Colland, J.A.Hickman, A.W.Roberts, D.C.Huang, A.H.Wei, A.Strasser, G.Lessene, O.Geneste.

ABSTRACT

No abstract given.