PDBsum entry 5k5c

Transferase

PDB id: 5k5c

Contents

Protein chain

461 a.a.

Ligands

GLC-GLC

NHE ×2

EDO ×8

Waters ×371

PDB id:

5k5c

Name:

Transferase

Title:

Structure of mycobacterium thermoresistibile trehalose-6-phosphate synthase in a complex with trehalose.

Structure:

Alpha,alpha-trehalose-phosphate synthase. Chain: a. Engineered: yes

Source:

Mycobacterium thermoresistibile. Organism_taxid: 1797. Atcc: 19527. Gene: rmct_1906, otsa. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008

Resolution:

1.85Å R-factor: 0.152 R-free: 0.175

Authors:

V.Mendes,N.Verma,M.Blaszczyk,T.L.Blundell

Key ref:

V.Mendes et al. Structure of mycobacterium thermoresistibile trehalose-6-Phosphate synthase reveals the mechanism substrate preference and a possible allosteric site.. To be published, . PubMed id: 31772052

Date:

23-May-16 Release date: 07-Jun-17

Protein chain

A0A117IMA6  (A0A117IMA6_MYCTH) -  alpha,alpha-trehalose-phosphate synthase (ADP-forming) from Mycolicibacterium thermoresistibile

Seq: 486 a.a.

Struc: 461 a.a.

Enzyme reactions

• Enzyme class: E.C.2.4.1.347 - alpha,alpha-trehalose-phosphate synthase (ADP-forming).
• Reaction: ADP-alpha-D-glucose + D-glucose 6-phosphate = alpha,alpha-trehalose 6-phosphate + ADP + H⁺

ADP-alpha-D-glucose + D-glucose 6-phosphate (Bound ligand (Het Group name = GLC) matches with 75.00% similarity) = alpha,alpha-trehalose 6-phosphate + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site