PDBsum entry 5fdh

Hydrolase

PDB id

5fdh

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Contents

			Protein chains

					242 a.a.

			Ligands

					SO4 ×12


					GOL ×2

			Waters ×434

PDB id:

5fdh

Links

Name:

Hydrolase

Title:

Crystal structure of oxa-405 beta-lactamase

Structure:

Beta-lactamase. Chain: a, b. Fragment: unp residues 23-261. Engineered: yes

Source:

Serratia marcescens. Organism_taxid: 615. Gene: blaoxa-405. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.26Å

R-factor:

0.177

R-free:

0.213

Authors:

P.Retailleau,S.Oueslati,L.Marchini,L.Dortet,T.Naas,B.Iorga

Key ref:

p.retailleau et al. (2019). Biochemical and Structural Characterization of OXA-405, an OXA-48 Variant with Extended-Spectrum beta-Lactamase Activity. Microorganisms, 8, . PubMed id: 31877796

Date:

16-Dec-15

Release date:

28-Dec-16

PROCHECK

	Headers

	References

Protein chains

A0A0F6P2I5 (A0A0F6P2I5_SERMA) - Beta-lactamase from Serratia marcescens

Seq: Struc:					261 a.a. 242 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 2 residue positions (black crosses)



		Enzyme reactions

Enzyme class:

E.C.3.5.2.6 - beta-lactamase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Penicillin Biosynthesis and Metabolism

Reaction:

a beta-lactam + H2O = a substituted beta-amino acid

Cofactor:

Zn(2+)

	Microorganisms 8: (2019)
PubMed id: 31877796

Biochemical and Structural Characterization of OXA-405, an OXA-48 Variant with Extended-Spectrum beta-Lactamase Activity.
p.retailleau, t.naas, b.iorga.

ABSTRACT

No abstract given.