PDBsum entry 5cin

Immune system

PDB id: 5cin

Contents

Protein chains

218 a.a.

212 a.a.

15 a.a.

Ligands

GOL ×4

Metals

_CL

Waters ×590

PDB id:

5cin

Name:

Immune system

Title:

Crystal structure of non-neutralizing version of 4e10 (deltaloop) with epitope bound

Structure:

Fab 4e10 heavy chain. Chain: h. Engineered: yes. Mutation: yes. Fab 4e10 light chain. Chain: l. Engineered: yes. Peptide from mper region of HIV-1 env. Chain: p.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008. Expression_system_variant: t7 shuffle. Synthetic: yes. Human immunodeficiency virus 1. Organism_taxid: 11676

Resolution:

1.70Å R-factor: 0.149 R-free: 0.178

Authors:

J.M.M.Caaveiro,E.Rujas,J.L.Nieva,K.Tsumoto

Key ref:

E.Rujas et al. (2015). Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10. J Virol, 89, 11975-11989. PubMed id: 26378169 DOI: 10.1128/JVI.01793-15

Date:

13-Jul-15 Release date: 23-Sep-15

Protein chain

No UniProt id for this chain

Struc: 218 a.a.

Protein chain

No UniProt id for this chain

Struc: 212 a.a.

Protein chain

P04578  (ENV_HV1H2) -  Envelope glycoprotein gp160 from Human immunodeficiency virus type 1 group M subtype B (isolate HXB2)

Seq: 856 a.a.

Struc: 15 a.a.*

* PDB and UniProt seqs differ at 3 residue positions (black crosses)

DOI no: 10.1128/JVI.01793-15

J Virol 89:11975-11989 (2015)

PubMed id: 26378169

Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10.

E.Rujas, N.Gulzar, K.Morante, K.Tsumoto, J.K.Scott, J.L.Nieva, J.M.Caaveiro.

ABSTRACT

No abstract given.