PDBsum entry 5eta

Transferase

PDB id: 5eta

Contents

Protein chains

335 a.a.

16 a.a.

Waters ×13

PDB id:

5eta

Name:

Transferase

Title:

Structure of mapk14 with bound the kim domain of the toxoplasma protein gra24

Structure:

Mitogen-activated protein kinase 14. Chain: b, a. Synonym: mapk 14,cytokine suppressive anti-inflammatory drug-binding protein,csbp,map kinase mxi2,max-interacting protein 2,mitogen- activated protein kinase p38 alpha,map kinase p38 alpha,stress- activated protein kinase 2a,sapk2a. Engineered: yes. Putative transmembrane protein. Chain: d, c.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk14, csbp, csbp1, csbp2, cspb1, mxi2, sapk2a. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Toxoplasma gondii. Organism_taxid: 5811

Resolution:

2.80Å R-factor: 0.223 R-free: 0.290

Authors:

E.Pellegrini,A.Palencia,L.Braun,U.Kapp,A.Bougdour,H.Belrhali, M.W.Bowler,M.Hakimi

Key ref:

E.Pellegrini et al. (2017). Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist. Structure, 25, 16-26. PubMed id: 27889209 DOI: 10.1016/j.str.2016.10.011

Date:

17-Nov-15 Release date: 26-Oct-16

Protein chains

Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14 from Homo sapiens

Seq: 360 a.a.

Struc: 335 a.a.

Protein chains

B6KJB6  (B6KJB6_TOXGV) -  Putative transmembrane protein from Toxoplasma gondii (strain ATCC 50861 / VEG)

Seq: 542 a.a.

Struc: 16 a.a.

Enzyme reactions

• Enzyme class: Chains B, A: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

DOI no: 10.1016/j.str.2016.10.011

Structure 25:16-26 (2017)

PubMed id: 27889209

Structural Basis for the Subversion of MAP Kinase Signaling by an Intrinsically Disordered Parasite Secreted Agonist.

E.Pellegrini, A.Palencia, L.Braun, U.Kapp, A.Bougdour, H.Belrhali, M.W.Bowler, M.A.Hakimi.

ABSTRACT

No abstract given.