PDBsum entry 4ztv

Transferase/transferase inhibitor

PDB id: 4ztv

Contents

Protein chains

339 a.a.

Ligands

TA7 ×2

Waters ×339

PDB id:

4ztv

Name:

Transferase/transferase inhibitor

Title:

Non-anthranilate-like inhibitor (tamu-a7) complexed with anthranilate phosphoribosyltransferase (trpd) from mycobacterium tuberculosis in absence of prpp

Structure:

Anthranilate phosphoribosyltransferase. Chain: a, b. Engineered: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 419947. Strain: atcc 25177 / h37ra. Gene: trpd, mra_2208. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

2.01Å R-factor: 0.196 R-free: 0.222

Authors:

G.L.Evans,J.Eom,E.N.Baker,J.S.Lott,Tb Structural Genomics Consortium (Tbsgc)

Key ref:

G.L.Evans et al. Bioactive non-Anthranilate-Like fragment-Like inhibit provides alternative starting point for inhibitor des against anthranilate phosphoribosyl transferase from mycobacterium tuberculosis.. To be published, .

Date:

15-May-15 Release date: 25-May-16

Protein chains

A5U4M0  (TRPD_MYCTA) -  Anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)

Seq: 370 a.a.

Struc: 339 a.a.

Enzyme reactions

• Enzyme class: E.C.2.4.2.18 - anthranilate phosphoribosyltransferase.
• Pathway: Tryptophan Biosynthesis
• Reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha- D-ribose 1-diphosphate + anthranilate

N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha- D-ribose 1-diphosphate + anthranilate (Bound ligand (Het Group name = TA7) matches with 42.11% similarity)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site