 |
PDBsum entry 4xdh
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Oxidoreductase
|
PDB id
|
|
|
|
4xdh
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Oxidoreductase
|
|
|
Title:
|
|
Crystal structure of quinone reductase ii in complex with a 2-(4- methoxy-phenyl)-5-methoxy-indol-3-one molecule
|
|
Structure:
|
|
Ribosyldihydronicotinamide dehydrogenase [quinone]. Chain: a, b. Synonym: quinone reductase ii,nrh dehydrogenase [quinone] 2, nrh:quinone oxidoreductase 2,quinone reductase 2,qr2. Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: nqo2, nmor2. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
Resolution:
|
|
|
1.90Å
|
R-factor:
|
0.172
|
R-free:
|
0.199
|
|
|
Authors:
|
|
S.Sirigu,F.Nepveu,L.Vuillard,G.Ferry,T.Isabet,A.Thompson,J.A.Boutin
|
|
Key ref:
|
|
f.nepveu
et al.
(2017).
Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives.
Molecules,
22,
.
PubMed id:
|
|
|
Date:
|
|
|
19-Dec-14
|
Release date:
|
13-Jan-16
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P16083
(NQO2_HUMAN) -
Ribosyldihydronicotinamide dehydrogenase [quinone] from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
231 a.a.
229 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.1.10.5.1
- ribosyldihydronicotinamide dehydrogenase (quinone).
|
|
|
|
|
|
|
Reaction:
|
|
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H+ = beta-nicotinamide D-riboside + a quinol
|
|
|
|
|
|
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide
Bound ligand (Het Group name = )
matches with 58.33% similarity
|
+
|
quinone
|
+
|
H(+)
|
=
|
beta-nicotinamide D-riboside
|
+
|
quinol
|
|
|
|
|
|
|
|
|
|
Cofactor:
|
|
FAD; Zn(2+)
|
|
|
|
|
|
FAD
Bound ligand (Het Group name =
FAD)
corresponds exactly
|
Zn(2+)
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
| |
|
|
Molecules
22:
(2017)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Role of Quinone Reductase 2 in the Antimalarial Properties of Indolone-Type Derivatives.
|
|
f.nepveu,
s.sirigu,
l.vuillard,
g.ferry,
t.isabet,
a.thompj.a.boutin.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Links
