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UniProt functional annotation for P16083 | ||
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| UniProt code: P16083. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis. {ECO:0000269|PubMed:18254726}. |
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| Catalytic activity: | |
Reaction=1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone + H(+) = a quinol + beta-nicotinamide D-riboside; Xref=Rhea:RHEA:12364, ChEBI:CHEBI:15378, ChEBI:CHEBI:15927, ChEBI:CHEBI:24646, ChEBI:CHEBI:55458, ChEBI:CHEBI:132124; EC=1.10.5.1; Evidence={ECO:0000269|PubMed:18579530}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| Cofactor: | |
Name=FAD; Xref=ChEBI:CHEBI:57692; |
| Activity regulation: | |
Inhibited by melatonin, resveratrol and 5- hydroxytryptamine. {ECO:0000269|PubMed:18254726}. |
| Biophysicochemical properties: | |
Kinetic parameters: KM=28 uM for NRH {ECO:0000269|PubMed:15078100, ECO:0000269|PubMed:9367528}; KM=11.6 uM for menadione {ECO:0000269|PubMed:15078100, ECO:0000269|PubMed:9367528}; KM=252 uM for NADH {ECO:0000269|PubMed:15078100, ECO:0000269|PubMed:9367528}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:15350128, ECO:0000269|PubMed:16129418, ECO:0000269|PubMed:18254726, ECO:0000269|PubMed:19236722}. |
| Subcellular location: | |
Cytoplasm. |
| Miscellaneous: | |
Uses dihydronicotinamide riboside (NRH) rather than NAD(P)H as an electron donor. |
| Similarity: | |
Belongs to the NAD(P)H dehydrogenase (quinone) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.