PDBsum entry 4l01

Transferase

PDB id: 4l01

Contents

Protein chain

274 a.a.

Waters ×221

PDB id:

4l01

Name:

Transferase

Title:

Crystal structure of the v658f apo jak1 pseudokinase domain

Structure:

Tyrosine-protein kinase jak1. Chain: a, b. Fragment: pseudokinase domain (unp residues 561-860). Synonym: janus kinase 1, jak-1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: jak1, jak1a, jak1b

Resolution:

1.90Å R-factor: 0.204 R-free: 0.233

Authors:

A.V.Toms,J.M.Rogers,M.J.Eck

Key ref:

A.V.Toms et al. (2013). Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases. Nat Struct Biol, 20, 1221-1223. PubMed id: 24013208 DOI: 10.1038/nsmb.2673

Date:

30-May-13 Release date: 04-Sep-13

Protein chains

P23458  (JAK1_HUMAN) -  Tyrosine-protein kinase JAK1 from Homo sapiens

Seq: 1154 a.a.

Struc: 274 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

DOI no: 10.1038/nsmb.2673

Nat Struct Biol 20:1221-1223 (2013)

PubMed id: 24013208

Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases.

A.V.Toms, A.Deshpande, R.McNally, Y.Jeong, J.M.Rogers, C.U.Kim, S.M.Gruner, S.B.Ficarro, J.A.Marto, M.Sattler, J.D.Griffin, M.J.Eck.

ABSTRACT

No abstract given.