PDBsum entry 4jt3

Transferase/transferase inhibitor

PDB id: 4jt3

Contents

Protein chain

254 a.a.

Ligands

PO4 ×4

1PH

EDO ×10

Waters ×30

PDB id:

4jt3

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of ttk kinase domain with an inhibitor: 400740

Structure:

Dual specificity protein kinase ttk. Chain: a. Fragment: kinase domain. Synonym: phosphotyrosine picked threonine-protein kinase, pyt. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: ttk, mps1, mps1l1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.20Å R-factor: 0.239 R-free: 0.251

Authors:

W.Qiu,M.Harris-Brandts,M.Feher,D.E.Awrey,N.Y.Chirgadze

Key ref:

W.Qiu et al. Crystal structure of ttk kinase domain with an inhibi 400740. To be published, .

Date:

22-Mar-13 Release date: 26-Mar-14

Protein chain

P33981  (TTK_HUMAN) -  Dual specificity protein kinase TTK from Homo sapiens

Seq: 857 a.a.

Struc: 254 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.12.1 - dual-specificity kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺
  3. L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site