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PDBsum entry 4jql
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Chaperone/inhibitor
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PDB id
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4jql
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PDB id:
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| Name: |
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Chaperone/inhibitor
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Title:
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Synthesis of benzoquinone-ansamycin-inspired macrocyclic lactams from shikimic acid
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Structure:
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Heat shock protein hsp 90-alpha. Chain: a. Synonym: heat shock 86 kda, hsp 86, hsp86, renal carcinoma antigen ny-ren-38. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: hsp90aa1, hsp90a, hspc1, hspca. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.72Å
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R-factor:
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0.169
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R-free:
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0.196
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Authors:
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V.Jeso,S.Iqbal,P.Hernandez,M.D.Cameron,H.Park,P.V.Lograsso, G.C.Micalizio
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Key ref:
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V.Jeso
et al.
(2013).
Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid.
Angew Chem Int Ed Engl,
52,
4800-4804.
PubMed id:
DOI:
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Date:
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20-Mar-13
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Release date:
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10-Apr-13
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PROCHECK
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Headers
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References
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P07900
(HS90A_HUMAN) -
Heat shock protein HSP 90-alpha from Homo sapiens
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Seq:
Struc:
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732 a.a.
215 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.3.6.4.10
- non-chaperonin molecular chaperone ATPase.
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Reaction:
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ATP + H2O = ADP + phosphate + H+
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ATP
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+
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H2O
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=
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ADP
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+
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phosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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DOI no:
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Angew Chem Int Ed Engl
52:4800-4804
(2013)
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PubMed id:
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Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid.
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V.Jeso,
S.Iqbal,
P.Hernandez,
M.D.Cameron,
H.Park,
P.V.LoGrasso,
G.C.Micalizio.
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ABSTRACT
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One is not like the other: The title approach proceeds by stepwise coupling of
three relatively simple substrates. Three natural product-inspired agents are
described, one of which has natural product-like toxicity for HeLa and MCF7
cells. It is isoform-selective, thus targeting Hsp90α/β over Grp94, and adopts
a conformation similar to that of geldanamycin when complexed with Hsp90.
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Links
