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PDBsum entry 4jql
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Chaperone/inhibitor
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PDB id
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4jql
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References listed in PDB file
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Key reference
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Title
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Synthesis of benzoquinone ansamycin-Inspired macrocyclic lactams from shikimic acid.
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Authors
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V.Jeso,
S.Iqbal,
P.Hernandez,
M.D.Cameron,
H.Park,
P.V.Lograsso,
G.C.Micalizio.
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Ref.
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Angew Chem Int Ed Engl, 2013,
52,
4800-4804.
[DOI no: ]
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PubMed id
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Abstract
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One is not like the other: The title approach proceeds by stepwise coupling of
three relatively simple substrates. Three natural product-inspired agents are
described, one of which has natural product-like toxicity for HeLa and MCF7
cells. It is isoform-selective, thus targeting Hsp90α/β over Grp94, and adopts
a conformation similar to that of geldanamycin when complexed with Hsp90.
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