PDBsum entry 4eyf

Hydrolase/antibiotic

PDB id

4eyf

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Contents

			Protein chains

					241 a.a.

			Ligands

					PNK ×2

			Metals

					_ZN ×6

			Waters ×310

PDB id:

4eyf

Links

Name:

Hydrolase/antibiotic

Title:

Crystal structure of ndm-1 bound to hydrolyzed benzylpenicillin

Structure:

Beta-lactamase ndm-1. Chain: a, b. Synonym: ndm-1, metallo-beta-lactamase ndm-1. Engineered: yes

Source:

Klebsiella pneumoniae. Organism_taxid: 573. Gene: blandm-1. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.80Å

R-factor:

0.164

R-free:

0.197

Authors:

N.C.J.Strynadka,D.T.King

Key ref:

D.T.King et al. (2012). New Delhi metallo-β-lactamase: structural insights into β-lactam recognition and inhibition. J Am Chem Soc, 134, 11362-11365. PubMed id: 22713171

Date:

01-May-12

Release date:

08-Aug-12

PROCHECK

	Headers

	References

Protein chains

C7C422 (BLAN1_KLEPN) - Metallo-beta-lactamase type 2 from Klebsiella pneumoniae

Seq: Struc:					270 a.a. 241 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class:

E.C.3.5.2.6 - beta-lactamase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Pathway:

Penicillin Biosynthesis and Metabolism

Reaction:

a beta-lactam + H2O = a substituted beta-amino acid

Cofactor:

Zn(2+)

	J Am Chem Soc 134:11362-11365 (2012)
PubMed id: 22713171

New Delhi metallo-β-lactamase: structural insights into β-lactam recognition and inhibition.
D.T.King, L.J.Worrall, R.Gruninger, N.C.Strynadka.

ABSTRACT

No abstract given.