PDBsum entry 4dgo

Transferase/transferase inhibitor

PDB id: 4dgo

Contents

Protein chain

325 a.a.

Ligands

0JW

Waters ×123

Obsolete entry

PDB id:

4dgo

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of maize ck2 in complex with tyrphostin ag99

Structure:

Casein kinase ii subunit alpha. Chain: a. Synonym: ck ii, ck2-alpha. Engineered: yes

Source:

Zea mays. Maize. Organism_taxid: 4577. Gene: ack2. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.96Å R-factor: 0.203 R-free: 0.230

Authors:

G.Lolli,M.Mazzorana,R.Battistutta

Key ref:

G.Lolli et al. (2012). Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight. Biochemistry, 51, 6097-6107. PubMed id: 22794353

Date:

26-Jan-12 Release date: 01-Aug-12

Protein chain

P28523  (CSK2A_MAIZE) -  Casein kinase II subunit alpha from Zea mays

Seq: 332 a.a.

Struc: 325 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Biochemistry 51:6097-6107 (2012)

PubMed id: 22794353

Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.

G.Lolli, G.Cozza, M.Mazzorana, E.Tibaldi, L.Cesaro, A.Donella-Deana, F.Meggio, A.Venerando, C.Franchin, S.Sarno, R.Battistutta, L.A.Pinna.

ABSTRACT

No abstract given.