PDBsum entry 4rae

Transferase

PDB id: 4rae

Contents

Protein chains

367 a.a.

PDB id:

4rae

Name:

Transferase

Title:

Crystal structure of rv1600 encoded aminotransferase from mycobacterium tuberculosis

Structure:

Histidinol-phosphate aminotransferase. Chain: a, b. Synonym: imidazole acetol-phosphate transaminase. Engineered: yes

Source:

Mycobacterium tuberculosis h37rv. Organism_taxid: 83332. Gene: hisc. Expressed in: mycobacterium smegmatis. Expression_system_taxid: 1772.

Resolution:

2.59Å R-factor: 0.241 R-free: 0.279

Authors:

N.Nasir,A.Anant,R.Vyas,B.K.Biswal

Key ref:

N.Nasir et al. Crystal structure of rv1600 encoded aminotransferase mycobacterium tuberculosis. To be published, .

Date:

10-Sep-14 Release date: 23-Sep-15

Protein chains

P9WML7  (HIS8_MYCTU) -  Histidinol-phosphate aminotransferase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 380 a.a.

Struc: 367 a.a.

Enzyme reactions

• Enzyme class: E.C.2.6.1.9 - histidinol-phosphate transaminase.
• Pathway: Histidine Biosynthesis (late stages)
• Reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate
• Cofactor: Pyridoxal 5'-phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site