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UniProt functional annotation for P9WML7 | ||
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| UniProt code: P9WML7. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Catalytic activity: | |
Reaction=2-oxoglutarate + L-histidinol phosphate = 3-(imidazol-4-yl)-2- oxopropyl phosphate + L-glutamate; Xref=Rhea:RHEA:23744, ChEBI:CHEBI:16810, ChEBI:CHEBI:29985, ChEBI:CHEBI:57766, ChEBI:CHEBI:57980; EC=2.6.1.9; |
| Cofactor: | |
Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326; Evidence={ECO:0000250}; |
| Pathway: | |
Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9. |
| Subunit: | |
Homodimer. {ECO:0000250}. |
| Miscellaneous: | |
Was identified as a high-confidence drug target. |
| Similarity: | |
Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.