PDBsum entry 4g3e

Transferase/transferase inhibitor

PDB id: 4g3e

Contents

Protein chains

314 a.a.

Ligands

SO4 ×3

0WC ×2

Waters ×61

PDB id:

4g3e

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of murine nf-kappab inducing kinase (nik) bound to a 6-alkynylindoline (cmp1)

Structure:

Nf-kappa-beta-inducing kinase. Chain: a, b. Synonym: serine/threonine-protein kinase nik. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: map3k14, nf-kappab inducing kinase, nik. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

2.50Å R-factor: 0.194 R-free: 0.240

Authors:

S.G.Hymowitz,G.De Leon-Boenig

Key ref:

G.de Leon-Boenig et al. (2012). The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site. Structure, 20, 1704-1714. PubMed id: 22921830

Date:

13-Jul-12 Release date: 15-Aug-12

Protein chains

Q9WUL6  (M3K14_MOUSE) -  Mitogen-activated protein kinase kinase kinase 14 from Mus musculus

Seq: 942 a.a.

Struc: 314 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.25 - mitogen-activated protein kinase kinase kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Structure 20:1704-1714 (2012)

PubMed id: 22921830

The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site.

G.de Leon-Boenig, K.K.Bowman, J.A.Feng, T.Crawford, C.Everett, Y.Franke, A.Oh, M.Stanley, S.T.Staben, M.A.Starovasnik, H.J.Wallweber, J.Wu, L.C.Wu, A.R.Johnson, S.G.Hymowitz.

ABSTRACT

No abstract given.