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PDBsum entry 4dfu
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Transferase/antibotic/inhibitor
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PDB id
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4dfu
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PDB id:
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| Name: |
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Transferase/antibotic/inhibitor
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Title:
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Inhibition of an antibiotic resistance enzyme: crystal structure of aminoglycoside phosphotransferase aph(2")-id/aph(2")-iva in complex with kanamycin inhibited with quercetin
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Structure:
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Aph(2")-id. Chain: a, b. Synonym: aph(2")-iva. Engineered: yes
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Source:
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Enterococcus casseliflavus. Organism_taxid: 37734. Gene: aph(2")-id. Expressed in: escherichia coli. Expression_system_taxid: 469008.
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Resolution:
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1.98Å
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R-factor:
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0.222
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R-free:
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0.270
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Authors:
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P.J.Stogios,G.Minasov,A.Dong,E.Evdokimova,E.Egorova,R.Di Leo,H.Li, T.Shakya,G.D.Wright,A.Savchenko,W.F.Anderson,Center For Structural Genomics Of Infectious Diseases (Csgid)
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Key ref:
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T.Shakya
et al.
(2011).
A small molecule discrimination map of the antibiotic resistance kinome.
Chem Biol,
18,
1591-1601.
PubMed id:
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Date:
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24-Jan-12
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Release date:
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08-Feb-12
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Supersedes:
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PROCHECK
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Headers
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References
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O68183
(O68183_ENTCA) -
APH(2'')-Id from Enterococcus casseliflavus
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Seq:
Struc:
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301 a.a.
296 a.a.
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Key: |
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Secondary structure |
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CATH domain |
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Chem Biol
18:1591-1601
(2011)
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PubMed id:
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A small molecule discrimination map of the antibiotic resistance kinome.
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T.Shakya,
P.J.Stogios,
N.Waglechner,
E.Evdokimova,
L.Ejim,
J.E.Blanchard,
A.G.McArthur,
A.Savchenko,
G.D.Wright.
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ABSTRACT
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Links
