PDBsum entry 3vev

Transferase/transferase activator

PDB id: 3vev

Contents

Protein chain

450 a.a.

Ligands

GLC

0H4

Metals

_NA

Waters ×362

PDB id:

3vev

Name:

Transferase/transferase activator

Title:

Glucokinase in complex with an activator and glucose

Structure:

Glucokinase. Chain: a. Fragment: unp residues 12-465. Synonym: hexokinase type iv, hk iv, hexokinase-4, hk4, hexokinase-d. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: gck. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

1.80Å R-factor: 0.174 R-free: 0.200

Authors:

S.Liu

Key ref:

S.Liu et al. (2012). Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations. J Biol Chem, 287, 13598-13610. PubMed id: 22298776

Date:

09-Jan-12 Release date: 08-Feb-12

Protein chain

P35557  (HXK4_HUMAN) -  Hexokinase-4 from Homo sapiens

Seq: 465 a.a.

Struc: 450 a.a.*

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.1.1 - hexokinase.
• Reaction: a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H⁺

D-hexose + ATP (Bound ligand (Het Group name = GLC) corresponds exactly) = D-hexose 6-phosphate + ADP + H(+)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

J Biol Chem 287:13598-13610 (2012)

PubMed id: 22298776

Insights into mechanism of glucokinase activation: observation of multiple distinct protein conformations.

S.Liu, M.J.Ammirati, X.Song, J.D.Knafels, J.Zhang, S.E.Greasley, J.A.Pfefferkorn, X.Qiu.

ABSTRACT

No abstract given.