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PDBsum entry 3vbf
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297 a.a.
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245 a.a.
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242 a.a.
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58 a.a.
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PDB id:
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Virus
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Title:
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Crystal structure of formaldehyde treated human enterovirus 71 (space group i23)
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Structure:
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Genome polyprotein, capsid protein vp1. Chain: a. Other_details: strain fuyang, anhui. P.R.C/17.08/1. Genome polyprotein, capsid protein vp2. Chain: b. Other_details: strain fuyang, anhui. P.R.C/17.08/1. Genome polyprotein, capsid protein vp3. Chain: c. Other_details: strain fuyang, anhui. P.R.C/17.08/1.
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Source:
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Human enterovirus 71. Organism_taxid: 39054. Other_details: grown in vero cells. Other_details: grown in vero cells
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Resolution:
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2.60Å
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R-factor:
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0.236
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R-free:
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0.240
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Authors:
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X.Wang,W.Peng,J.Ren,Z.Hu,J.Xu,Z.Lou,X.Li,W.Yin,X.Shen,C.Porta, T.S.Walter,G.Evans,D.Axford,R.Owen,D.J.Rowlands,J.Wang,D.I.Stuart, E.E.Fry,Z.Rao
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Key ref:
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X.Wang
et al.
(2012).
A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.
Nat Struct Biol,
19,
424-429.
PubMed id:
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Date:
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02-Jan-12
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Release date:
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29-Feb-12
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PROCHECK
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Headers
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References
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B2ZUN0
(B2ZUN0_HE71) -
Genome polyprotein from Human enterovirus 71
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Seq:
Struc:
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2193 a.a.
297 a.a.*
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B2ZUN0
(B2ZUN0_HE71) -
Genome polyprotein from Human enterovirus 71
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Seq:
Struc:
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2193 a.a.
245 a.a.
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Enzyme class 2:
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Chains A, B, C, D:
E.C.2.7.7.48
- RNA-directed Rna polymerase.
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Reaction:
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RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate
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RNA(n)
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+
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ribonucleoside 5'-triphosphate
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=
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RNA(n+1)
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+
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diphosphate
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Enzyme class 3:
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Chains A, B, C, D:
E.C.3.4.22.28
- picornain 3C.
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Reaction:
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Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 4:
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Chains A, B, C, D:
E.C.3.4.22.29
- picornain 2A.
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Reaction:
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Selective cleavage of Tyr-|-Gly bond in the picornavirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
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Enzyme class 5:
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Chains A, B, C, D:
E.C.3.6.1.15
- nucleoside-triphosphate phosphatase.
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Reaction:
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a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + phosphate + H+
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ribonucleoside 5'-triphosphate
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+
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H2O
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=
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ribonucleoside 5'-diphosphate
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+
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phosphate
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Nat Struct Biol
19:424-429
(2012)
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PubMed id:
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A sensor-adaptor mechanism for enterovirus uncoating from structures of EV71.
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X.Wang,
W.Peng,
J.Ren,
Z.Hu,
J.Xu,
Z.Lou,
X.Li,
W.Yin,
X.Shen,
C.Porta,
T.S.Walter,
G.Evans,
D.Axford,
R.Owen,
D.J.Rowlands,
J.Wang,
D.I.Stuart,
E.E.Fry,
Z.Rao.
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ABSTRACT
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