PDBsum entry 3v1q

Hydrolase

PDB id

3v1q

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Contents

			Protein chain

					157 a.a.

			Waters ×80

PDB id:

3v1q

Links

Name:

Hydrolase

Title:

Crystal structures of the reverse transcriptase-associated ribonuclease h domain of xenotropic murine leukemia-virus related virus

Structure:

Reverse transcriptase/ribonuclease h p80. Chain: a. Fragment: rnase h domain (unp residues 1155-1328). Engineered: yes

Source:

Xenotropic mulv-related virus vp35. Xmrv. Organism_taxid: 356663. Gene: gag-pol, pol_xmrv3. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.00Å

R-factor:

0.172

R-free:

0.198

Authors:

D.Zhou,A.Wlodawer

Key ref:

D.Zhou et al. (2012). Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus. J Struct Biol, 177, 638-645. PubMed id: 22366278

Date:

09-Dec-11

Release date:

14-Mar-12

PROCHECK

	Headers

	References

Protein chain

Q2F7J3 (POL_XMRV3) - Gag-Pol polyprotein from Xenotropic MuLV-related virus (isolate VP35)

Seq: Struc:

Seq: Struc:

Seq: Struc:

Seq: Struc:					1733 a.a. 157 a.a.

Key:

PfamA domain

Secondary structure

CATH domain



		Enzyme reactions

Enzyme class 2:

E.C.2.7.7.- - ?????

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Enzyme class 3:

E.C.2.7.7.49 - RNA-directed Dna polymerase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate

DNA(n)	+	2'-deoxyribonucleoside 5'-triphosphate	=	DNA(n+1)	+	diphosphate

Enzyme class 4:

E.C.2.7.7.7 - DNA-directed Dna polymerase.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate

DNA(n)	+	2'-deoxyribonucleoside 5'-triphosphate	=	DNA(n+1)	+	diphosphate

Enzyme class 5:

E.C.3.1.-.-

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Enzyme class 6:

E.C.3.1.26.4 - ribonuclease H.

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Reaction:

Endonucleolytic cleavage to 5'-phosphomonoester.

Enzyme class 7:

E.C.3.4.23.- - ?????

[IntEnz] [ExPASy] [KEGG] [BRENDA]

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

	J Struct Biol 177:638-645 (2012)
PubMed id: 22366278

Crystal structures of the reverse transcriptase-associated ribonuclease H domain of xenotropic murine leukemia-virus related virus.
D.Zhou, S.Chung, M.Miller, S.F.Grice, A.Wlodawer.

ABSTRACT

No abstract given.