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PDBsum entry 3pyd
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PDB id:
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Transferase
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Title:
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Crystal structure of 4-diphosphocytidyl-2-c-methyl-d-erythritol kinase (ispe) from mycobacterium tuberculosis
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Structure:
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4-diphosphocytidyl-2-c-methyl-d-erythritol kinase. Chain: a. Synonym: ispe, cmk, 4-(cytidine-5'-diphospho)-2-c-methyl-d-erythritol kinase. Engineered: yes
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Source:
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Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: ispe, rv1011, mt1040, mtci237.28. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.10Å
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R-factor:
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0.197
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R-free:
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0.244
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Authors:
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S.Shan,X.H.Chen,T.Liu,H.C.Zhao,Z.H.Rao,Z.Y.Lou
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Key ref:
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S.Shan
et al.
The structural basis for anti-Tb drug discovery targe 4-Diphosphocytidyl-2-C-Methyl-D-Erythritol kinase (is from mycobacterium tuberculosis.
To be published,
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Date:
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13-Dec-10
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Release date:
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25-Jan-12
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PROCHECK
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Headers
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References
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P9WKG7
(ISPE_MYCTU) -
4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
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Seq:
Struc:
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318 a.a.
298 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.1.148
- 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase.
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Reaction:
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4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + H+
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4-CDP-2-C-methyl-D-erythritol
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+
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ATP
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=
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4-CDP-2-C-methyl-D-erythritol 2-phosphate
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+
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ADP
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+
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H(+)
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Cofactor:
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Mn(2+) or Mg(2+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
