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UniProt functional annotation for P9WKG7 | ||
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| UniProt code: P9WKG7. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. {ECO:0000255|HAMAP- Rule:MF_00061}. |
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| Catalytic activity: | |
Reaction=4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D- erythritol 2-phosphate + ADP + H(+); Xref=Rhea:RHEA:18437, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57823, ChEBI:CHEBI:57919, ChEBI:CHEBI:456216; EC=2.7.1.148; Evidence={ECO:0000255|HAMAP-Rule:MF_00061}; |
| Pathway: | |
Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via DXP pathway; isopentenyl diphosphate from 1-deoxy-D-xylulose 5- phosphate: step 3/6. {ECO:0000255|HAMAP-Rule:MF_00061}. |
| Miscellaneous: | |
Was identified as a high-confidence drug target. |
| Similarity: | |
Belongs to the GHMP kinase family. IspE subfamily. {ECO:0000255|HAMAP-Rule:MF_00061}. |
Annotations taken from UniProtKB at the EBI.