PDBsum entry 3py7

Viral protein

PDB id: 3py7

Contents

Protein chain

500 a.a.

Ligands

GLC-GLC-GLC

Metals

_ZN ×2

Waters ×186

PDB id:

3py7

Name:

Viral protein

Title:

Crystal structure of full-length bovine papillomavirus oncoprotein e6 in complex with ld1 motif of paxillin at 2.3a resolution

Structure:

Maltose-binding periplasmic protein,paxillin ld1,protein e6 chimera. Chain: a. Engineered: yes. Mutation: yes

Source:

Escherichia coli, bovine papillomavirus type 1, homo sapiens. Organism_taxid: 562, 10559, 9606. Gene: male,pxn,e6. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.29Å R-factor: 0.189 R-free: 0.225

Authors:

J.Cavarelli

Key ref:

K.Zanier et al. (2013). Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins. Science, 339, 694-698. PubMed id: 23393263

Date:

12-Dec-10 Release date: 14-Dec-11

Protein chain

P06931  (VE6_BPV1) -  Protein E6 from Bovine papillomavirus type 1

Seq: 137 a.a.

Struc: 500 a.a.*

Protein chain

P0AEX9  (MALE_ECOLI) -  Maltose/maltodextrin-binding periplasmic protein from Escherichia coli (strain K12)

Seq: 396 a.a.

Struc: 500 a.a.*

* PDB and UniProt seqs differ at 18 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.?

Science 339:694-698 (2013)

PubMed id: 23393263

Structural basis for hijacking of cellular LxxLL motifs by papillomavirus E6 oncoproteins.

K.Zanier, S.Charbonnier, A.O.Sidi, A.G.McEwen, M.G.Ferrario, P.Poussin-Courmontagne, V.Cura, N.Brimer, K.O.Babah, T.Ansari, I.Muller, R.H.Stote, J.Cavarelli, S.Vande Pol, G.Travé.

ABSTRACT

No abstract given.