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UniProt functional annotation for P06931 | ||
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| UniProt code: P06931. |
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| Organism: | |
Bovine papillomavirus type 1. |
| Taxonomy: | |
Viruses; Monodnaviria; Shotokuvirae; Cossaviricota; Papovaviricetes; Zurhausenvirales; Papillomaviridae; Firstpapillomavirinae; Deltapapillomavirus. |
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| Function: | |
Plays a major role in the induction and maintenance of cellular transformation. E6 associates with host UBE3A/E6-AP ubiquitin- protein ligase and modulates its activity. Protects host keratinocytes from apoptosis by mediating the degradation of host BAK1. May also inhibit host immune response. {ECO:0000255|HAMAP-Rule:MF_04006}. |
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| Subunit: | |
Forms homodimers. Interacts with ubiquitin-protein ligase UBE3A/E6-AP; this interaction stimulates UBE3A ubiquitin activity. Interacts with host BAK1. Interacts with human FBLN1. {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000269|PubMed:12200142}. |
| Subcellular location: | |
Host cytoplasm {ECO:0000255|HAMAP-Rule:MF_04006}. Host nucleus {ECO:0000255|HAMAP-Rule:MF_04006}. |
| Similarity: | |
Belongs to the papillomaviridae E6 protein family. {ECO:0000255|HAMAP-Rule:MF_04006, ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.