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PDBsum entry 3og8
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Hydrolase/RNA
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PDB id
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3og8
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Contents |
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* Residue conservation analysis
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PDB id:
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Hydrolase/RNA
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Title:
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Crystal structure of human rig-i ctd bound to a 14-bp blunt-ended dsrna
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Structure:
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Antiviral innate immune response receptor rig-i. Chain: a, b. Fragment: c-terminal domain. Synonym: atp-dependent RNA helicase ddx58,dead box protein 58,rig-i- like receptor 1,rlr-1,RNA sensor rig-i,retinoic acid-inducible gene 1 protein,rig-1,retinoic acid-inducible gene i protein,rig-i. Engineered: yes. Mutation: yes. RNA (5'-r( Gp Gp Cp Gp Cp Gp Cp Gp Cp Gp Cp Gp Cp C)-3').
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: rigi, ddx58. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Synthetic construct. Organism_taxid: 32630.
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Resolution:
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2.40Å
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R-factor:
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0.217
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R-free:
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0.278
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Authors:
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P.Li
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Key ref:
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C.Lu
et al.
(2011).
Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate.
Nucleic Acids Res,
39,
1565-1575.
PubMed id:
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Date:
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16-Aug-10
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Release date:
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03-Nov-10
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PROCHECK
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Headers
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References
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O95786
(DDX58_HUMAN) -
Antiviral innate immune response receptor RIG-I from Homo sapiens
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Seq:
Struc:
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925 a.a.
126 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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G-G-C-G-C-G-C-G-C-G-C-G-C-C
14 bases
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G-G-C-G-C-G-C-G-C-G-C-G-C-C
14 bases
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Enzyme class:
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E.C.3.6.4.13
- Rna helicase.
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Reaction:
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ATP + H2O = ADP + phosphate + H+
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ATP
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+
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H2O
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=
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ADP
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+
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phosphate
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Nucleic Acids Res
39:1565-1575
(2011)
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PubMed id:
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Crystal structure of RIG-I C-terminal domain bound to blunt-ended double-strand RNA without 5' triphosphate.
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C.Lu,
C.T.Ranjith-Kumar,
L.Hao,
C.C.Kao,
P.Li.
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ABSTRACT
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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F.Jiang,
A.Ramanathan,
M.T.Miller,
G.Q.Tang,
M.Gale,
S.S.Patel,
and
J.Marcotrigiano
(2011).
Structural basis of RNA recognition and activation by innate immune receptor RIG-I.
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Nature,
479,
423-427.
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PDB codes:
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The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
Where a reference describes a PDB structure, the PDB
codes are
shown on the right.
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Links
