PDBsum entry 3mxr

Hydrolase/hydrolase inhibitor

PDB id: 3mxr

Contents

Protein chain

265 a.a.

Ligands

CZ8

MA4 ×2

Waters ×266

PDB id:

3mxr

Name:

Hydrolase/hydrolase inhibitor

Title:

Shv-1 beta-lactamase complex with compound 1

Structure:

Beta-lactamase shv-1. Chain: a. Synonym: pit-2. Engineered: yes

Source:

Klebsiella pneumoniae. Organism_taxid: 573. Gene: bla, shv1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.30Å R-factor: 0.186 R-free: 0.203

Authors:

W.Ke,F.Van Den Akker

Key ref:

W.Ke et al. (2011). Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors. Antimicrob Agents Chemother, 55, 174-183. PubMed id: 21041505

Date:

07-May-10 Release date: 24-Nov-10

Protein chain

P0AD64  (BLA1_KLEPN) -  Beta-lactamase SHV-1 from Klebsiella pneumoniae

Seq: 286 a.a.

Struc: 265 a.a.

Enzyme reactions

• Enzyme class: E.C.3.5.2.6 - beta-lactamase.
• Pathway: Penicillin Biosynthesis and Metabolism
• Reaction: a beta-lactam + H2O = a substituted beta-amino acid
• Cofactor: Zn(2+)

Antimicrob Agents Chemother 55:174-183 (2011)

PubMed id: 21041505

Novel insights into the mode of inhibition of class A SHV-1 beta-lactamases revealed by boronic acid transition state inhibitors.

W.Ke, J.M.Sampson, C.Ori, F.Prati, S.M.Drawz, C.R.Bethel, R.A.Bonomo, F.van den Akker.

ABSTRACT

No abstract given.