PDBsum entry 3vnt

Transferase/transferase inhibitor

PDB id: 3vnt

Contents

Protein chain

301 a.a.

Ligands

0JA

EDO ×3

Waters ×253

PDB id:

3vnt

Name:

Transferase/transferase inhibitor

Title:

Crystal structure of the kinase domain of human vegfr2 with a [1, 3]thiazolo[5,4-b]pyridine derivative

Structure:

Vascular endothelial growth factor receptor 2. Chain: a. Fragment: unp residues 806-1171. Synonym: vegfr-2, fetal liver kinase 1, flk-1, kinase insert domain receptor, kdr, protein-tyrosine kinase receptor flk-1. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: kdr, flk1, vegfr2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

1.64Å R-factor: 0.153 R-free: 0.192

Authors:

H.Oki

Key ref:

M.Okaniwa et al. (2012). Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds. J Med Chem, 55, 3452-3478. PubMed id: 22376051

Date:

17-Jan-12 Release date: 11-Apr-12

Protein chain

P35968  (VGFR2_HUMAN) -  Vascular endothelial growth factor receptor 2 from Homo sapiens

Seq: 1356 a.a.

Struc: 301 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.1 - receptor protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

J Med Chem 55:3452-3478 (2012)

PubMed id: 22376051

Design and synthesis of novel DFG-out RAF/vascular endothelial growth factor receptor 2 (VEGFR2) inhibitors. 1. Exploration of [5,6]-fused bicyclic scaffolds.

M.Okaniwa, M.Hirose, T.Imada, T.Ohashi, Y.Hayashi, T.Miyazaki, T.Arita, M.Yabuki, K.Kakoi, J.Kato, T.Takagi, T.Kawamoto, S.Yao, A.Sumita, S.Tsutsumi, T.Tottori, H.Oki, B.C.Sang, J.Yano, K.Aertgeerts, S.Yoshida, T.Ishikawa.

ABSTRACT

No abstract given.