PDBsum entry 3uc5

Transferase

PDB id: 3uc5

Contents

Protein chain

157 a.a.

Ligands

ATP

Waters ×59

PDB id:

3uc5

Name:

Transferase

Title:

Phosphopantetheine adenylyltransferase from mycobacterium tuberculosis complexed with atp

Structure:

Phosphopantetheine adenylyltransferase. Chain: a. Synonym: dephospho-coa pyrophosphorylase, pantetheine-phosphate adenylyltransferase, ppat. Engineered: yes

Source:

Mycobacterium tuberculosis. Organism_taxid: 1773. Gene: coad, kdtb, rv2965c, mt3043, mtcy349.22, u0002e. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

1.70Å R-factor: 0.179 R-free: 0.222

Authors:

V.I.Timofeev,E.A.Smirnova,L.A.Chupova,R.S.Esipov,I.P.Kuranova

Key ref:

V.Timofeev et al. (2012). X-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reaction. Acta Crystallogr D Biol Crystallogr, 68, 1660-1670. PubMed id: 23151631

Date:

26-Oct-11 Release date: 07-Nov-12

Protein chain

P9WPA5  (COAD_MYCTU) -  Phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)

Seq: 161 a.a.

Struc: 157 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.7.3 - pantetheine-phosphate adenylyltransferase.
• Pathway: Coenzyme A Biosynthesis (late stages)
• Reaction: (R)-4'-phosphopantetheine + ATP + H⁺ = 3'-dephospho-CoA + diphosphate

(R)-4'-phosphopantetheine + ATP (Bound ligand (Het Group name = ATP) corresponds exactly) + H(+) = 3'-dephospho-CoA + diphosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Acta Crystallogr D Biol Crystallogr 68:1660-1670 (2012)

PubMed id: 23151631

X-ray study of the conformational changes in the molecule of phosphopantetheine adenylyltransferase from Mycobacterium tuberculosis during the catalyzed reaction.

V.Timofeev, E.Smirnova, L.Chupova, R.Esipov, I.Kuranova.

ABSTRACT

No abstract given.