PDBsum entry 3u2d

Isomerase/isomerase inhibitor

PDB id: 3u2d

Contents

Protein chains

194 a.a.

Ligands

08B ×2

Metals

_MG ×4

Waters ×324

PDB id:

3u2d

Name:

Isomerase/isomerase inhibitor

Title:

S. Aureus gyrb atpase domain in complex with small molecule inhibitor

Structure:

DNA gyrase subunit b. Chain: a, b. Fragment: atpase domain with loop deletion, unp residues 14-104 and 128-233. Engineered: yes

Source:

Staphylococcus aureus. Organism_taxid: 1280. Gene: gyrb. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

1.85Å R-factor: 0.202 R-free: 0.232

Authors:

P.A.Boriack-Sjodin,D.B.Prince,A.E.Eakin,B.A.Sherer

Key ref:

A.E.Eakin et al. (2012). Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents. Antimicrob Agents Chemother, 56, 1240-1246. PubMed id: 22183167

Date:

03-Oct-11 Release date: 11-Jan-12

Protein chains

P0A0K8  (GYRB_STAAU) -  DNA gyrase subunit B from Staphylococcus aureus

Seq: 644 a.a.

Struc: 194 a.a.

Enzyme reactions

• Enzyme class: E.C.5.6.2.2 - Dna topoisomerase (ATP-hydrolyzing).

Antimicrob Agents Chemother 56:1240-1246 (2012)

PubMed id: 22183167

Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.

A.E.Eakin, O.Green, N.Hales, G.K.Walkup, S.Bist, A.Singh, G.Mullen, J.Bryant, K.Embrey, N.Gao, A.Breeze, D.Timms, B.Andrews, M.Uria-Nickelsen, J.Demeritt, J.T.Loch, K.Hull, A.Blodgett, R.N.Illingworth, B.Prince, P.A.Boriack-Sjodin, S.Hauck, L.J.MacPherson, H.Ni, B.Sherer.

ABSTRACT

No abstract given.