PDBsum entry 3qa8

Immune system, signaling protein

PDB id: 3qa8

Contents

Protein chains

(+ 0 more) 622 a.a.

541 a.a.

PDB id:

3qa8

Name:

Immune system, signaling protein

Title:

Crystal structure of inhibitor of kappa b kinase beta

Structure:

Mgc80376 protein. Chain: a, b, c, d, e, f, g, h. Mutation: yes

Source:

Xenopus laevis. Clawed frog,common platanna,platanna. Organism_taxid: 8355

Resolution:

3.60Å R-factor: 0.310 R-free: 0.344

Authors:

G.Xu,Y.C.Lo,Q.Li,G.Napolitano,X.Wu,X.Jiang,M.Dreano,M.Karin,H.Wu

Key ref:

G.Xu et al. (2011). Crystal structure of inhibitor of κB kinase β. Nature, 472, 325-330. PubMed id: 21423167

Date:

10-Jan-11 Release date: 06-Apr-11

Protein chains

Q6INT1  (Q6INT1_XENLA) -  IkappaB kinase from Xenopus laevis

Seq: 742 a.a.

Struc: 622 a.a.*

Protein chains

Q6INT1  (Q6INT1_XENLA) -  IkappaB kinase from Xenopus laevis

Seq: 742 a.a.

Struc: 541 a.a.*

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D, E, F, G, H: E.C.2.7.11.10 - IkappaB kinase.
• Reaction: L-seryl-[I-kappa-B protein] + ATP = O-phospho-L-seryl-[I-kappa-B protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Nature 472:325-330 (2011)

PubMed id: 21423167

Crystal structure of inhibitor of κB kinase β.

G.Xu, Y.C.Lo, Q.Li, G.Napolitano, X.Wu, X.Jiang, M.Dreano, M.Karin, H.Wu.

ABSTRACT

No abstract given.