PDBsum entry 3oxq

Metal binding protein/transport protein

PDB id: 3oxq

Contents

Protein chains

145 a.a. *

127 a.a. *

64 a.a. *

Metals

_CA ×14

Waters ×97

* Residue conservation analysis

PDB id:

3oxq

Name:

Metal binding protein/transport protein

Title:

Crystal structure of ca2+/cam-cav1.2 pre-iq/iq domain complex

Structure:

Calmodulin. Chain: a, b, c, d. Synonym: cam. Engineered: yes. Voltage-dependent l-type calcium channel subunit alpha-1c. Chain: e, f. Fragment: preiq/iq domain (unp residues 1609-1685). Synonym: voltage-gated calcium channel subunit alpha cav1.2, calcium channel, l type, alpha-1 polypeptide, isoform 1, cardiac muscle.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: calm, calm1, calm2, calm3, calml2, calmodulin (cam), cam, cam1, cam2, cam3, camb, camc, camiii. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: cach2, cacn2, cacna1c, cacnl1a1, calcium channel cav1.2, cchl1a1.

Resolution:

2.55Å R-factor: 0.243 R-free: 0.288

Authors:

E.Y.Kim,C.H.Rumpf,F.Van Petegem,R.Arant,F.Findeisen,E.S.Cooley, E.Y.Isacoff,D.L.Minor

Key ref:

E.Y.Kim et al. (2010). Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization. Embo J, 29, 3924-3938. PubMed id: 20953164

Date:

21-Sep-10 Release date: 03-Nov-10

Protein chains

P0DP23  (CALM1_HUMAN) -  Calmodulin-1 from Homo sapiens

Seq: 149 a.a.

Struc: 145 a.a.

Protein chains

P0DP23  (CALM1_HUMAN) -  Calmodulin-1 from Homo sapiens

Seq: 149 a.a.

Struc: 127 a.a.

Protein chains

Q13936  (CAC1C_HUMAN) -  Voltage-dependent L-type calcium channel subunit alpha-1C from Homo sapiens

Seq: 2221 a.a.

Struc: 64 a.a.*

* PDB and UniProt seqs differ at 1 residue position (black cross)

Embo J 29:3924-3938 (2010)

PubMed id: 20953164

Multiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerization.

E.Y.Kim, C.H.Rumpf, F.Van Petegem, R.J.Arant, F.Findeisen, E.S.Cooley, E.Y.Isacoff, D.L.Minor.

ABSTRACT

No abstract given.