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PDBsum entry 3eam
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Membrane protein, transport protein
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PDB id
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3eam
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Membrane protein, transport protein
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Title:
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An open-pore structure of a bacterial pentameric ligand-gated ion channel
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Structure:
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Glr4197 protein. Chain: a, b, c, d, e. Fragment: unp residues 43-359. Engineered: yes
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Source:
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Gloeobacter violaceus. Organism_taxid: 33072. Gene: glr4197. Expressed in: escherichia coli. Expression_system_taxid: 562.
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Resolution:
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2.90Å
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R-factor:
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0.200
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R-free:
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0.231
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Authors:
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N.Bocquet,H.Nury,M.Baaden,C.Le Poupon,J.P.Changeux,M.Delarue, P.J.Corringer
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Key ref:
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N.Bocquet
et al.
(2009).
X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation.
Nature,
457,
111-114.
PubMed id:
DOI:
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Date:
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26-Aug-08
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Release date:
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04-Nov-08
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PROCHECK
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Headers
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References
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Q7NDN8
(GLIC_GLOVI) -
Proton-gated ion channel from Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)
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Seq:
Struc:
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359 a.a.
311 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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DOI no:
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Nature
457:111-114
(2009)
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PubMed id:
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X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation.
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N.Bocquet,
H.Nury,
M.Baaden,
C.Le Poupon,
J.P.Changeux,
M.Delarue,
P.J.Corringer.
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ABSTRACT
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Pentameric ligand-gated ion channels from the Cys-loop family mediate fast
chemo-electrical transduction, but the mechanisms of ion permeation and gating
of these membrane proteins remain elusive. Here we present the X-ray structure
at 2.9 A resolution of the bacterial Gloeobacter violaceus pentameric
ligand-gated ion channel homologue (GLIC) at pH 4.6 in an apparently open
conformation. This cationic channel is known to be permanently activated by
protons. The structure is arranged as a funnel-shaped transmembrane pore widely
open on the outer side and lined by hydrophobic residues. On the inner side, a 5
A constriction matches with rings of hydrophilic residues that are likely to
contribute to the ionic selectivity. Structural comparison with ELIC, a
bacterial homologue from Erwinia chrysanthemi solved in a presumed closed
conformation, shows a wider pore where the narrow hydrophobic constriction found
in ELIC is removed. Comparative analysis of GLIC and ELIC reveals, in concert, a
rotation of each extracellular beta-sandwich domain as a rigid body, interface
rearrangements, and a reorganization of the transmembrane domain, involving a
tilt of the M2 and M3 alpha-helices away from the pore axis. These data are
consistent with a model of pore opening based on both quaternary twist and
tertiary deformation.
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Selected figure(s)
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Figure 1.
Figure 1: GLIC structure. a, Ribbon representation of GLIC
viewed from the plane of the membrane. DDM molecules bound in
the channel are depicted as yellow sticks plus van der Waals
surface. Horizontal lines represent the membrane limits. b,
Transmembrane part of GLIC viewed from the extracellular side.
The ECD is removed for clarity. Lipids are also depicted in
orange. c, Topology of a GLIC subunit. The conserved core
elements common to GLIC and ELIC are coloured in yellow. d,
Close-up view of the TMD. Only two subunits are represented. The
DDM molecules and the lipids (named LIP601/2/3) close to these
subunits are coloured according to their atomic B-factor (colour
scale at top).
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Figure 3.
Figure 3: Open GLIC and closed ELIC structure comparison. a,
Side view of the structural superposition. For the two subunits
in the foreground, only the common core is depicted, in green
for GLIC, in red for ELIC. Other subunits are in grey. The ECD
rotation axes and the twist axis are depicted. The M4 helix is
omitted for clarity. b, Close-up view of the interface between
the ECD and the TMD (side view in left panel and upper view in
right panel). c, Close-up of transmembrane helices M1–M3
viewed from the channel.
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The above figures are
reprinted
by permission from Macmillan Publishers Ltd:
Nature
(2009,
457,
111-114)
copyright 2009.
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Figures were
selected
by an automated process.
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Literature references that cite this PDB file's key reference
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PubMed id
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Reference
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M.S.Prevost,
L.Sauguet,
H.Nury,
C.Van Renterghem,
C.Huon,
F.Poitevin,
M.Baaden,
M.Delarue,
and
P.J.Corringer
(2012).
A locally closed conformation of a bacterial pentameric proton-gated ion channel.
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Nat Struct Mol Biol,
19,
642-649.
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PDB codes:
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C.J.daCosta,
R.Michel Sturgeon,
A.K.Hamouda,
M.P.Blanton,
and
J.E.Baenziger
(2011).
Structural characterization and agonist binding to human α4β2 nicotinic receptors.
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Biochem Biophys Res Commun,
407,
456-460.
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C.S.Gandhi,
T.A.Walton,
and
D.C.Rees
(2011).
OCAM: a new tool for studying the oligomeric diversity of MscL channels.
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Protein Sci,
20,
313-326.
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H.Nury,
C.Van Renterghem,
Y.Weng,
A.Tran,
M.Baaden,
V.Dufresne,
J.P.Changeux,
J.M.Sonner,
M.Delarue,
and
P.J.Corringer
(2011).
X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel.
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Nature,
469,
428-431.
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PDB codes:
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J.E.Baenziger,
and
P.J.Corringer
(2011).
3D structure and allosteric modulation of the transmembrane domain of pentameric ligand-gated ion channels.
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Neuropharmacology,
60,
116-125.
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N.Dimitropoulos,
A.Papakyriakou,
G.A.Dalkas,
C.T.Chasapis,
K.Poulas,
and
G.A.Spyroulias
(2011).
A computational investigation on the role of glycosylation in the binding of alpha1 nicotinic acetylcholine receptor with two alpha-neurotoxins.
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Proteins,
79,
142-152.
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R.E.Hibbs,
and
E.Gouaux
(2011).
Principles of activation and permeation in an anion-selective Cys-loop receptor.
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Nature,
474,
54-60.
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PDB codes:
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R.E.Hubbard
(2011).
Structure-based drug discovery and protein targets in the CNS.
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Neuropharmacology,
60,
7.
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S.A.Forman
(2011).
Clinical and molecular pharmacology of etomidate.
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Anesthesiology,
114,
695-707.
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S.M.Hanson,
and
C.Czajkowski
(2011).
Disulphide trapping of the GABA(A) receptor reveals the importance of the coupling interface in the action of benzodiazepines.
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Br J Pharmacol,
162,
673-687.
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S.Murail,
B.Wallner,
J.R.Trudell,
E.Bertaccini,
and
E.Lindahl
(2011).
Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.
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Biophys J,
100,
1642-1650.
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S.V.Jadey,
P.Purohit,
I.Bruhova,
T.M.Gregg,
and
A.Auerbach
(2011).
Design and control of acetylcholine receptor conformational change.
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Proc Natl Acad Sci U S A,
108,
4328-4333.
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T.Sander,
B.Frølund,
A.T.Bruun,
I.Ivanov,
J.A.McCammon,
and
T.Balle
(2011).
New insights into the GABA(A) receptor structure and orthosteric ligand binding: receptor modeling guided by experimental data.
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Proteins,
79,
1458-1477.
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W.Zheng,
and
A.Auerbach
(2011).
Decrypting the sequence of structural events during the gating transition of pentameric ligand-gated ion channels based on an interpolated elastic network model.
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PLoS Comput Biol,
7,
e1001046.
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A.Birdsey-Benson,
A.Gill,
L.P.Henderson,
and
D.R.Madden
(2010).
Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors.
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J Neurosci,
30,
1463-1470.
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PDB codes:
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A.Estrada-Mondragón,
J.M.Reyes-Ruiz,
A.Martínez-Torres,
and
R.Miledi
(2010).
Structure-function study of the fourth transmembrane segment of the GABAρ1 receptor.
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Proc Natl Acad Sci U S A,
107,
17780-17784.
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A.I.Herrera,
A.Al-Rawi,
G.A.Cook,
J.Gao,
T.Iwamoto,
O.Prakash,
J.M.Tomich,
and
J.Chen
(2010).
Structural characterization of two pore-forming peptides: consequences of introducing a C-terminal tryptophan.
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Proteins,
78,
2238-2250.
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A.J.Thompson,
H.A.Lester,
and
S.C.Lummis
(2010).
The structural basis of function in Cys-loop receptors.
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Q Rev Biophys,
43,
449-499.
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C.Song,
and
B.Corry
(2010).
Ion conduction in ligand-gated ion channels: Brownian dynamics studies of four recent crystal structures.
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Biophys J,
98,
404-411.
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F.J.Barrantes,
V.Bermudez,
M.V.Borroni,
S.S.Antollini,
M.F.Pediconi,
J.C.Baier,
I.Bonini,
C.Gallegos,
A.M.Roccamo,
A.S.Valles,
V.Ayala,
and
C.Kamerbeek
(2010).
Boundary lipids in the nicotinic acetylcholine receptor microenvironment.
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J Mol Neurosci,
40,
87-90.
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F.Zhu,
and
G.Hummer
(2010).
Pore opening and closing of a pentameric ligand-gated ion channel.
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Proc Natl Acad Sci U S A,
107,
19814-19819.
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G.Brannigan,
D.N.LeBard,
J.Hénin,
R.G.Eckenhoff,
and
M.L.Klein
(2010).
Multiple binding sites for the general anesthetic isoflurane identified in the nicotinic acetylcholine receptor transmembrane domain.
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Proc Natl Acad Sci U S A,
107,
14122-14127.
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H.Nury,
F.Poitevin,
C.Van Renterghem,
J.P.Changeux,
P.J.Corringer,
M.Delarue,
and
M.Baaden
(2010).
One-microsecond molecular dynamics simulation of channel gating in a nicotinic receptor homologue.
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Proc Natl Acad Sci U S A,
107,
6275-6280.
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PDB code:
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H.X.Zhou,
and
J.A.McCammon
(2010).
The gates of ion channels and enzymes.
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Trends Biochem Sci,
35,
179-185.
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I.Bahar,
T.R.Lezon,
A.Bakan,
and
I.H.Shrivastava
(2010).
Normal mode analysis of biomolecular structures: functional mechanisms of membrane proteins.
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Chem Rev,
110,
1463-1497.
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I.Bahar
(2010).
On the functional significance of soft modes predicted by coarse-grained models for membrane proteins.
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J Gen Physiol,
135,
563-573.
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I.H.Yamodo,
D.C.Chiara,
J.B.Cohen,
and
K.W.Miller
(2010).
Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization.
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Biochemistry,
49,
156-165.
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J.A.Lundbaek,
S.A.Collingwood,
H.I.Ingólfsson,
R.Kapoor,
and
O.S.Andersen
(2010).
Lipid bilayer regulation of membrane protein function: gramicidin channels as molecular force probes.
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J R Soc Interface,
7,
373-395.
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J.M.Cederholm,
N.L.Absalom,
S.Sugiharto,
R.Griffith,
P.R.Schofield,
and
T.M.Lewis
(2010).
Conformational changes in extracellular loop 2 associated with signal transduction in the glycine receptor.
|
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J Neurochem,
115,
1245-1255.
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J.P.Changeux
(2010).
Allosteric receptors: from electric organ to cognition.
|
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Annu Rev Pharmacol Toxicol,
50,
1.
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J.Todorovic,
B.T.Welsh,
E.J.Bertaccini,
J.R.Trudell,
and
S.J.Mihic
(2010).
Disruption of an intersubunit electrostatic bond is a critical step in glycine receptor activation.
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Proc Natl Acad Sci U S A,
107,
7987-7992.
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K.R.Vinothkumar,
and
R.Henderson
(2010).
Structures of membrane proteins.
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Q Rev Biophys,
43,
65.
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M.Criado,
J.Mulet,
M.Castillo,
S.Gerber,
S.Sala,
and
F.Sala
(2010).
The loop between beta-strands beta2 and beta3 and its interaction with the N-terminal alpha-helix is essential for biogenesis of alpha7 nicotinic receptors.
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J Neurochem,
112,
103-111.
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O.K.Steinlein,
and
D.Bertrand
(2010).
Nicotinic receptor channelopathies and epilepsy.
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Pflugers Arch,
460,
495-503.
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P.S.Miller,
and
T.G.Smart
(2010).
Binding, activation and modulation of Cys-loop receptors.
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Trends Pharmacol Sci,
31,
161-174.
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P.Taylor
(2010).
Defining the determinants of nicotine selectivity.
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Proc Natl Acad Sci U S A,
107,
13195-13196.
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R.J.Hilf,
C.Bertozzi,
I.Zimmermann,
A.Reiter,
D.Trauner,
and
R.Dutzler
(2010).
Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel.
|
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Nat Struct Mol Biol,
17,
1330-1336.
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PDB codes:
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S.Haeger,
D.Kuzmin,
S.Detro-Dassen,
N.Lang,
M.Kilb,
V.Tsetlin,
H.Betz,
B.Laube,
and
G.Schmalzing
(2010).
An intramembrane aromatic network determines pentameric assembly of Cys-loop receptors.
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Nat Struct Mol Biol,
17,
90-98.
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S.J.Edelstein,
and
J.P.Changeux
(2010).
Relationships between structural dynamics and functional kinetics in oligomeric membrane receptors.
|
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Biophys J,
98,
2045-2052.
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S.M.Sine,
H.L.Wang,
S.Hansen,
and
P.Taylor
(2010).
On the origin of ion selectivity in the Cys-loop receptor family.
|
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J Mol Neurosci,
40,
70-76.
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T.Cui,
C.G.Canlas,
Y.Xu,
and
P.Tang
(2010).
Anesthetic effects on the structure and dynamics of the second transmembrane domains of nAChR alpha4beta2.
|
| |
Biochim Biophys Acta,
1798,
161-166.
|
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U.Das,
J.Kumar,
M.L.Mayer,
and
A.J.Plested
(2010).
Domain organization and function in GluK2 subtype kainate receptors.
|
| |
Proc Natl Acad Sci U S A,
107,
8463-8468.
|
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Y.Weng,
L.Yang,
P.J.Corringer,
and
J.M.Sonner
(2010).
Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel.
|
| |
Anesth Analg,
110,
59-63.
|
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|
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|
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Z.Dostalova,
A.Liu,
X.Zhou,
S.L.Farmer,
E.S.Krenzel,
E.Arevalo,
R.Desai,
P.L.Feinberg-Zadek,
P.A.Davies,
I.H.Yamodo,
S.A.Forman,
and
K.W.Miller
(2010).
High-level expression and purification of Cys-loop ligand-gated ion channels in a tetracycline-inducible stable mammalian cell line: GABAA and serotonin receptors.
|
| |
Protein Sci,
19,
1728-1738.
|
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A.Guilfoyle,
M.J.Maher,
M.Rapp,
R.Clarke,
S.Harrop,
and
M.Jormakka
(2009).
Structural basis of GDP release and gating in G protein coupled Fe2+ transport.
|
| |
EMBO J,
28,
2677-2685.
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PDB codes:
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A.Jha,
P.Purohit,
and
A.Auerbach
(2009).
Energy and structure of the M2 helix in acetylcholine receptor-channel gating.
|
| |
Biophys J,
96,
4075-4084.
|
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|
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A.Taly,
P.J.Corringer,
D.Guedin,
P.Lestage,
and
J.P.Changeux
(2009).
Nicotinic receptors: allosteric transitions and therapeutic targets in the nervous system.
|
| |
Nat Rev Drug Discov,
8,
733-750.
|
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C.J.daCosta,
and
J.E.Baenziger
(2009).
A lipid-dependent uncoupled conformation of the acetylcholine receptor.
|
| |
J Biol Chem,
284,
17819-17825.
|
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C.J.daCosta,
S.A.Medaglia,
N.Lavigne,
S.Wang,
C.L.Carswell,
and
J.E.Baenziger
(2009).
Anionic lipids allosterically modulate multiple nicotinic acetylcholine receptor conformational equilibria.
|
| |
J Biol Chem,
284,
33841-33849.
|
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|
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C.Melis,
G.Bussi,
S.C.Lummis,
and
C.Molteni
(2009).
Trans-cis Switching Mechanisms in Proline Analogues and Their Relevance for the Gating of the 5-HT(3) Receptor.
|
| |
J Phys Chem B,
113,
12148-12153.
|
|
|
|
|
|
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C.Song,
and
B.Corry
(2009).
Computational study of the transmembrane domain of the acetylcholine receptor.
|
| |
Eur Biophys J,
38,
961-970.
|
|
|
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|
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D.C.Chiara,
A.K.Hamouda,
M.R.Ziebell,
L.A.Mejia,
G.Garcia,
and
J.B.Cohen
(2009).
[(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel.
|
| |
Biochemistry,
48,
10066-10077.
|
|
|
|
|
|
|
D.I.Perkins,
J.R.Trudell,
D.K.Crawford,
L.Asatryan,
R.L.Alkana,
and
D.L.Davies
(2009).
Loop 2 structure in glycine and GABA(A) receptors plays a key role in determining ethanol sensitivity.
|
| |
J Biol Chem,
284,
27304-27314.
|
|
|
|
|
|
|
D.Langosch,
and
I.T.Arkin
(2009).
Interaction and conformational dynamics of membrane-spanning protein helices.
|
| |
Protein Sci,
18,
1343-1358.
|
|
|
|
|
|
|
F.Zhu,
and
G.Hummer
(2009).
Gating transition of pentameric ligand-gated ion channels.
|
| |
Biophys J,
97,
2456-2463.
|
|
|
|
|
|
|
H.L.Wang,
R.Toghraee,
D.Papke,
X.L.Cheng,
J.A.McCammon,
U.Ravaioli,
and
S.M.Sine
(2009).
Single-channel current through nicotinic receptor produced by closure of binding site C-loop.
|
| |
Biophys J,
96,
3582-3590.
|
|
|
|
|
|
|
J.Wu
(2009).
Understanding of nicotinic acetylcholine receptors.
|
| |
Acta Pharmacol Sin,
30,
653-655.
|
|
|
|
|
|
|
K.Matsuda,
S.Kanaoka,
M.Akamatsu,
and
D.B.Sattelle
(2009).
Diverse actions and target-site selectivity of neonicotinoids: structural insights.
|
| |
Mol Pharmacol,
76,
1.
|
|
|
|
|
|
|
L.Adamian,
H.A.Gussin,
Y.Y.Tseng,
N.J.Muni,
F.Feng,
H.Qian,
D.R.Pepperberg,
and
J.Liang
(2009).
Structural model of rho1 GABAC receptor based on evolutionary analysis: Testing of predicted protein-protein interactions involved in receptor assembly and function.
|
| |
Protein Sci,
18,
2371-2383.
|
|
|
|
|
|
|
L.T.Liu,
D.Willenbring,
Y.Xu,
and
P.Tang
(2009).
General anesthetic binding to neuronal alpha4beta2 nicotinic acetylcholine receptor and its effects on global dynamics.
|
| |
J Phys Chem B,
113,
12581-12589.
|
|
|
|
|
|
|
M.Castillo,
J.Mulet,
M.Aldea,
S.Gerber,
S.Sala,
F.Sala,
and
M.Criado
(2009).
Role of the N-terminal alpha-helix in biogenesis of alpha7 nicotinic receptors.
|
| |
J Neurochem,
108,
1399-1409.
|
|
|
|
|
|
|
M.H.Cheng,
Y.Xu,
and
P.Tang
(2009).
Anionic lipid and cholesterol interactions with alpha4beta2 nAChR: insights from MD simulations.
|
| |
J Phys Chem B,
113,
6964-6970.
|
|
|
|
|
|
|
N.L.Absalom,
P.R.Schofield,
and
T.M.Lewis
(2009).
Pore structure of the Cys-loop ligand-gated ion channels.
|
| |
Neurochem Res,
34,
1805-1815.
|
|
|
|
|
|
|
N.Vogel,
C.J.Kluck,
N.Melzer,
S.Schwarzinger,
U.Breitinger,
S.Seeber,
and
C.M.Becker
(2009).
Mapping of disulfide bonds within the amino-terminal extracellular domain of the inhibitory glycine receptor.
|
| |
J Biol Chem,
284,
36128-36136.
|
|
|
|
|
|
|
P.A.Bafna,
A.Jha,
and
A.Auerbach
(2009).
Aromatic Residues {epsilon}Trp-55 and {delta}Trp-57 and the Activation of Acetylcholine Receptor Channels.
|
| |
J Biol Chem,
284,
8582-8588.
|
|
|
|
|
|
|
R.E.Hibbs,
G.Sulzenbacher,
J.Shi,
T.T.Talley,
S.Conrod,
W.R.Kem,
P.Taylor,
P.Marchot,
and
Y.Bourne
(2009).
Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal alpha7 nicotinic acetylcholine receptor.
|
| |
EMBO J,
28,
3040-3051.
|
|
|
PDB codes:
|
|
|
|
|
|
|
|
S.A.Pless,
and
J.W.Lynch
(2009).
Ligand-specific conformational changes in the alpha1 glycine receptor ligand-binding domain.
|
| |
J Biol Chem,
284,
15847-15856.
|
|
|
|
|
|
|
S.A.Pless,
and
J.W.Lynch
(2009).
Magnitude of a conformational change in the glycine receptor beta1-beta2 loop is correlated with agonist efficacy.
|
| |
J Biol Chem,
284,
27370-27376.
|
|
|
|
|
|
|
Y.C.Chang,
W.Wu,
J.L.Zhang,
and
Y.Huang
(2009).
Allosteric activation mechanism of the cys-loop receptors.
|
| |
Acta Pharmacol Sin,
30,
663-672.
|
|
|
|
|
|
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Citation data come partly from CiteXplore and partly
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Where a reference describes a PDB structure, the PDB
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