PDBsum entry 3aso

Oxidoreductase

PDB id: 3aso

Contents

Protein chains

514 a.a.

227 a.a.

259 a.a.

144 a.a.

105 a.a.

98 a.a.

84 a.a.

79 a.a.

73 a.a.

58 a.a.

49 a.a.

46 a.a.

43 a.a.

Ligands

HEA ×4

TGL ×6

PGV ×8

CUA ×2

PSC ×2

CHD ×8

UNX ×2

PEK ×6

CDL ×4

DMU ×2

Metals

_ZN ×2

_CU ×2

_MG ×2

_NA ×2

Waters ×1711

PDB id:

3aso

Name:

Oxidoreductase

Title:

Bovine heart cytochromE C oxidase in the fully oxidized state measured at 0.9 angstrom wavelength

Structure:

CytochromE C oxidase subunit 1. Chain: a, n. Synonym: cytochromE C oxidase polypeptide i. CytochromE C oxidase subunit 2. Chain: b, o. Synonym: cytochromE C oxidase polypeptide ii. CytochromE C oxidase subunit 3. Chain: c, p. Synonym: cytochromE C oxidase polypeptide iii.

Source:

Bos taurus. Bovine. Organism_taxid: 9913. Organism_taxid: 9913

Resolution:

2.30Å R-factor: 0.169 R-free: 0.205

Authors:

M.Suga,N.Yano,K.Muramoto,K.Shinzawa-Itoh,T.Maeda,E.Yamashita, T.Tsukihara,S.Yoshikawa

Key ref:

M.Suga et al. (2011). Distinguishing between Cl- and O2(2-) as the bridging element between Fe3+ and Cu2+ in resting-oxidized cytochrome c oxidase. Acta Crystallogr D Biol Crystallogr, 67, 742-744. PubMed id: 21795816

Date:

17-Dec-10 Release date: 03-Aug-11

Protein chains

P00396  (COX1_BOVIN) -  Cytochrome c oxidase subunit 1 from Bos taurus

Seq: 514 a.a.

Struc: 514 a.a.*

Protein chains

P68530  (COX2_BOVIN) -  Cytochrome c oxidase subunit 2 from Bos taurus

Seq: 227 a.a.

Struc: 227 a.a.*

Protein chains

P00415  (COX3_BOVIN) -  Cytochrome c oxidase subunit 3 from Bos taurus

Seq: 261 a.a.

Struc: 259 a.a.

Protein chains

P00423  (COX41_BOVIN) -  Cytochrome c oxidase subunit 4 isoform 1, mitochondrial from Bos taurus

Seq: 169 a.a.

Struc: 144 a.a.

Protein chains

P00426  (COX5A_BOVIN) -  Cytochrome c oxidase subunit 5A, mitochondrial from Bos taurus

Seq: 152 a.a.

Struc: 105 a.a.

Protein chains

P00428  (COX5B_BOVIN) -  Cytochrome c oxidase subunit 5B, mitochondrial from Bos taurus

Seq: 129 a.a.

Struc: 98 a.a.

Protein chains

P07471  (CX6A2_BOVIN) -  Cytochrome c oxidase subunit 6A2, mitochondrial from Bos taurus

Seq: 97 a.a.

Struc: 84 a.a.*

Protein chains

P00429  (CX6B1_BOVIN) -  Cytochrome c oxidase subunit 6B1 from Bos taurus

Seq: 86 a.a.

Struc: 79 a.a.

Protein chains

P04038  (COX6C_BOVIN) -  Cytochrome c oxidase subunit 6C from Bos taurus

Seq: 74 a.a.

Struc: 73 a.a.*

Protein chains

P07470  (CX7A1_BOVIN) -  Cytochrome c oxidase subunit 7A1, mitochondrial from Bos taurus

Seq: 80 a.a.

Struc: 58 a.a.

Protein chains

P13183  (COX7B_BOVIN) -  Cytochrome c oxidase subunit 7B, mitochondrial from Bos taurus

Seq: 80 a.a.

Struc: 49 a.a.

Protein chains

P00430  (COX7C_BOVIN) -  Cytochrome c oxidase subunit 7C, mitochondrial from Bos taurus

Seq: 63 a.a.

Struc: 46 a.a.

Protein chains

P10175  (COX8B_BOVIN) -  Cytochrome c oxidase subunit 8B, mitochondrial from Bos taurus

Seq: 70 a.a.

Struc: 43 a.a.

* PDB and UniProt seqs differ at 4 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, N, O, P: E.C.7.1.1.9 - cytochrome-c oxidase.
• Reaction: 4 Fe(II)-[cytochrome c] + O2 + 8 H⁺(in) = 4 Fe(III)-[cytochrome c] + 2 H2O + 4 H⁺(out)
• Cofactor: Cu cation

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

Acta Crystallogr D Biol Crystallogr 67:742-744 (2011)

PubMed id: 21795816

Distinguishing between Cl- and O2(2-) as the bridging element between Fe3+ and Cu2+ in resting-oxidized cytochrome c oxidase.

M.Suga, N.Yano, K.Muramoto, K.Shinzawa-Itoh, T.Maeda, E.Yamashita, T.Tsukihara, S.Yoshikawa.

ABSTRACT

No abstract given.