PDBsum entry 3ac3

Transferase

PDB id: 3ac3

Contents

Protein chain

272 a.a. *

Ligands

SO4 ×2

KSH

Waters ×135

* Residue conservation analysis

PDB id:

3ac3

Name:

Transferase

Title:

Crystal structure of pyrazolo pyrimidine derivative bound to the kinase domain of human lck, (auto-phosphorylated on tyr394)

Structure:

Proto-oncogene tyrosine-protein kinase lck. Chain: a. Fragment: unp residues 225-509. Synonym: lymphocyte kinase, lck, lymphocyte cell-specific protein- tyrosine kinase, p56-lck, lsk, t cell-specific protein-tyrosine kinase. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: lck. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108.

Resolution:

2.55Å R-factor: 0.209 R-free: 0.274

Authors:

E.Tsuji

Key ref:

M.Ozawa et al. Ab initio fragment molecular orbital study of ligand binding to leukocyte-Specific protein tyrosine (lck). To be published, .

Date:

28-Dec-09 Release date: 30-Jun-10

Protein chain

P06239  (LCK_HUMAN) -  Tyrosine-protein kinase Lck from Homo sapiens

Seq: 509 a.a.

Struc: 272 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site