 |
PDBsum entry 2oad
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transferase
|
|
|
Title:
|
|
Structure of glutathione-s-transferase c169a mutant
|
|
Structure:
|
|
Glutathione s-transferase p 1. Chain: a, b. Synonym: gst yf-yf, gst-pib, gst class-pi, gst p1, preadipocyte growth factor. Engineered: yes. Mutation: yes
|
|
Source:
|
|
Mus musculus. House mouse. Organism_taxid: 10090. Gene: gstp1, gstpib. Expressed in: escherichia coli. Expression_system_taxid: 562
|
|
Resolution:
|
|
|
2.50Å
|
R-factor:
|
0.216
|
R-free:
|
0.264
|
|
|
Authors:
|
|
O.J.Kyrieleis,G.Mcmanus,T.J.Mantle,A.R.Khan
|
|
Key ref:
|
|
O.J.Kyrieleis
et al.
Structural and kinetic analyses of glutathione s-Transferase mutations.
To be published,
.
|
|
|
Date:
|
|
|
15-Dec-06
|
Release date:
|
23-Jan-07
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P19157
(GSTP1_MOUSE) -
Glutathione S-transferase P 1 from Mus musculus
|
|
|
|
Seq:
Struc:
|
|
|
|
210 a.a.
209 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.2.5.1.18
- glutathione transferase.
|
|
|
|
|
|
|
Reaction:
|
|
RX + glutathione = an S-substituted glutathione + a halide anion + H+
|
|
|
|
|
|
RX
Bound ligand (Het Group name = )
matches with 66.67% similarity
|
+
|
glutathione
|
=
|
S-substituted glutathione
|
+
|
halide anion
|
+
|
H(+)
|
|
|
|
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
Links
