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PDBsum entry 2hex
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protein ligands Protein-protein interface(s) links
Blood clotting PDB id
2hex

 

 

 

 

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Contents
Protein chains
56 a.a. *
Ligands
SO4 ×8
Waters ×181
* Residue conservation analysis
PDB id:
2hex
Name: Blood clotting
Title: Decamers observed in the crystals of bovine pancreatic trypsin inhibitor
Structure: Protein (pancreatic trypsin inhibitor). Chain: a, b, c, d, e
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: pancreas
Biol. unit: Decamer (from PQS)
Resolution:
2.10Å     R-factor:   0.205     R-free:   0.288
Authors: J.Lubkowski,A.Wlodawer
Key ref:
J.Lubkowski and A.Wlodawer (1999). Decamers observed in the crystals of bovine pancreatic trypsin inhibitor. Acta Crystallogr D Biol Crystallogr, 55, 335-337. PubMed id: 10089443 DOI: 10.1107/S0907444998011068
Date:
01-Aug-98     Release date:   05-Aug-99    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P00974  (BPT1_BOVIN) -  Pancreatic trypsin inhibitor from Bos taurus
Seq:
Struc: 		100 a.a.
56 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 

 
DOI no: 10.1107/S0907444998011068 Acta Crystallogr D Biol Crystallogr 55:335-337 (1999)
PubMed id: 10089443  
 
 
Decamers observed in the crystals of bovine pancreatic trypsin inhibitor.
J.Lubkowski, A.Wlodawer.
 
  ABSTRACT  
 
The structure of bovine pancreatic trypsin inhibitor (BPTI) has been solved at 2.1 A resolution in a new crystal form (space group P6422 with unit-cell dimensions a = b = 95.0, c = 158.1 A). The asymmetric unit is a pentamer, but a decamer is created by application of crystallographic symmetry. The decamer of BPTI is only the fourth such assembly reported to date in the Protein Data Bank.
 
  Selected figure(s)  
 
Figure 1.
Figure 1 Stereoscopic drawing of the C traces for four representative previously determined pentamers and two decamers, compared with the currently obtained structure of BPTI. (a) Cholera toxin, (b) C-reactive protein, (c) mouse polyomavirus VP1 coat protein, (d) cartilage oligomeric matrix protein, (e) GTP cyclohydrolase I, (f) muconolactone isomerase, (g) cyclophilin A, (h) BPTI (this work).
 
  The above figure is reprinted by permission from the IUCr: Acta Crystallogr D Biol Crystallogr (1999, 55, 335-337) copyright 1999.  

Literature references that cite this PDB file's key reference Google scholar

  PubMed id Reference
15665132 K.Snoussi, and B.Halle (2005).
Protein self-association induced by macromolecular crowding: a quantitative analysis by magnetic relaxation dispersion.
  Biophys J, 88, 2855-2866.  
12770900 M.Gottschalk, K.Venu, and B.Halle (2003).
Protein self-association in solution: the bovine pancreatic trypsin inhibitor decamer.
  Biophys J, 84, 3941-3958.  
  10716178 R.St Charles, K.Padmanabhan, R.V.Arni, K.P.Padmanabhan, and A.Tulinsky (2000).
Structure of tick anticoagulant peptide at 1.6 A resolution complexed with bovine pancreatic trypsin inhibitor.
  Protein Sci, 9, 265-272.
PDB code: 1d0d
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

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