 |
PDBsum entry 2fvh
|
|
|
|
|
 |
Contents |
 |
|
|
|
|
|
|
|
|
|
|
* Residue conservation analysis
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Hydrolase
|
|
|
Title:
|
|
Crystal structure of rv1848, a urease gamma subunit urea (urea amidohydrolase), from mycobacterium tuberculosis
|
|
Structure:
|
|
Urease gamma subunit. Chain: a, b, c. Synonym: urea amidohydrolase gamma subunit. Engineered: yes
|
|
Source:
|
|
Mycobacterium tuberculosis. Organism_taxid: 1773. Strain: h32rv. Gene: urea. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
|
|
Biol. unit:
|
|
Trimer (from
)
|
|
Resolution:
|
|
|
1.80Å
|
R-factor:
|
0.186
|
R-free:
|
0.229
|
|
|
Authors:
|
|
E.H.Bursey,M.Yu,Tb Structural Genomics Consortium (Tbsgc),T.Lekin, B.Rupp,C.Y.Kim,B.S.Rho,T.C.Terwilliger
|
|
Key ref:
|
|
E.H.Bursey
et al.
Crystal structure of rv1848, A urease gamma subunit urea (urea amidohydrolase), From mycobacterium tuberculosis.
To be published,
.
|
|
|
Date:
|
|
|
30-Jan-06
|
Release date:
|
07-Feb-06
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
P9WFE7
(URE3_MYCTU) -
Urease subunit gamma from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
|
|
|
|
Seq:
Struc:
|
|
|
|
100 a.a.
99 a.a.
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
|
|
|
|
|
|
|
|
|
|
|
Enzyme class:
|
|
E.C.3.5.1.5
- urease.
|
|
|
|
|
|
|
Reaction:
|
|
urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+
|
|
|
|
|
|
urea
|
+
|
2
×
H2O
|
+
|
H(+)
|
=
|
hydrogencarbonate
|
+
|
2
×
NH4(+)
|
|
|
|
|
|
|
|
|
|
Cofactor:
|
|
Ni(2+)
|
|
|
|
|
|
|
|
|
Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
|
|
|
|
Links
