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UniProt functional annotation for P9WFE7 | ||
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| UniProt code: P9WFE7. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Catalytic activity: | |
Reaction=2 H(+) + H2O + urea = CO2 + 2 NH4(+); Xref=Rhea:RHEA:20557, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16199, ChEBI:CHEBI:16526, ChEBI:CHEBI:28938; EC=3.5.1.5; Evidence={ECO:0000255|HAMAP-Rule:MF_00739, ECO:0000269|PubMed:7559354}; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=0.3 mM for urea {ECO:0000269|PubMed:7559354}; Vmax=0.05 mmol/min/mg enzyme {ECO:0000269|PubMed:7559354}; pH dependence: Optimum pH is 7.2. {ECO:0000269|PubMed:7559354}; |
| Pathway: | |
Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. {ECO:0000255|HAMAP-Rule:MF_00739}. |
| Subunit: | |
Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. |
| Subcellular location: | |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00739}. |
| Similarity: | |
Belongs to the urease gamma subunit family. {ECO:0000255|HAMAP-Rule:MF_00739}. |
Annotations taken from UniProtKB at the EBI.