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PDBsum entry 2eiy
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protein ligands Protein-protein interface(s) links
Transferase PDB id
2eiy

 

 

 

 

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Contents
Protein chains
297 a.a. *
Ligands
PLP ×3
4MV ×3
MPD ×5
Waters ×913
* Residue conservation analysis
PDB id:
2eiy
Name: Transferase
Title: Crystal structure of t.Th.Hb8 branched-chain amino acid aminotransferase complexed with 4-methylvaleric acid
Structure: Branched-chain amino acid aminotransferase. Chain: a, b, c. Synonym: ilve. Engineered: yes
Source: Thermus thermophilus. Organism_taxid: 300852. Strain: hb8. Expressed in: escherichia coli bl21(de3). Expression_system_taxid: 469008.
Resolution:
1.35Å     R-factor:   0.189     R-free:   0.201
Authors: M.Goto
Key ref: M.Goto Crystal structure of t.Th.Hb8 branched-Chain amino acid aminotransferase complexed with 4-Methylvaleric acid. To be published, .
Date:
14-Mar-07     Release date:   18-Mar-08    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q5SM19  (Q5SM19_THET8) -  Branched-chain-amino-acid aminotransferase from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
Seq:
Struc: 		308 a.a.
297 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.6.1.42  - branched-chain-amino-acid transaminase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway: 		Leucine Biosynthesis
      Reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate
L-leucine
 +
2-oxoglutarate
Bound ligand (Het Group name = 4MV)
matches with 88.89% similarity 		= 4-methyl-2-oxopentanoate
 + L-glutamate
      Cofactor: Pyridoxal 5'-phosphate
Pyridoxal 5'-phosphate
Bound ligand (Het Group name = PLP) matches with 93.75% similarity
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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