PDBsum entry 2ds4

Protein binding

PDB id: 2ds4

Contents

Protein chain

113 a.a. *

* Residue conservation analysis

PDB id:

2ds4

Name:

Protein binding

Title:

Solution structure of the filamin domain from human tripartite motif protein 45

Structure:

Tripartite motif protein 45. Chain: a. Fragment: filamin domain. Synonym: ring finger protein 99. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: trim45. Other_details: cell-free protein synthesis

NMR struc:

20 models

Authors:

T.Tomizawa,S.Koshiba,S.Watanabe,T.Harada,T.Kigawa,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

T.Tomizawa et al. Solution structure of the filamin domain from human tripartite motif protein 45. To be published, .

Date:

21-Jun-06 Release date: 21-Dec-06

Protein chain

Q9H8W5  (TRI45_HUMAN) -  E3 ubiquitin-protein ligase TRIM45 from Homo sapiens

Seq: 580 a.a.

Struc: 113 a.a.*

* PDB and UniProt seqs differ at 8 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.3.2.27 - RING-type E3 ubiquitin transferase.
• Reaction: S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N₆- ubiquitinyl-[acceptor protein]-L-lysine