PDBsum entry 2ziq

Hydrolase/hydrolase inhibitor

PDB id: 2ziq

Contents

Protein chains

28 a.a. *

251 a.a. *

Ligands

ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYS-LEU

26U

BEN

Metals

_NA ×2

Waters ×179

* Residue conservation analysis

PDB id:

2ziq

Name:

Hydrolase/hydrolase inhibitor

Title:

Thrombin inhibition

Structure:

Thrombin light chain. Chain: l. Synonym: coagulation factor ii. Thrombin heavy chain. Chain: h. Synonym: coagulation factor ii. Hirudin variant-1. Chain: i. Fragment: residues 54-64.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Tissue: blood plasma. Synthetic: yes. Hirudo medicinalis. Organism_taxid: 6421. Other_details: synthetic fragment of hirudin from hirudo medicinalis

Resolution:

1.65Å R-factor: 0.187 R-free: 0.225

Authors:

B.Baum,A.Heine,G.Klebe

Key ref:

B.Baum et al. Understanding thrombin inhibition. To be published, .

Date:

20-Feb-08 Release date: 13-Jan-09

Protein chain

P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens

Seq: 622 a.a.

Struc: 28 a.a.

Protein chain

P00734  (THRB_HUMAN) -  Prothrombin from Homo sapiens

Seq: 622 a.a.

Struc: 251 a.a.

Enzyme reactions

• Enzyme class: Chains L, H: E.C.3.4.21.5 - thrombin.
• Reaction: Preferential cleavage: Arg-|-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B.