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PDBsum entry 2xfq
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Oxidoreductase
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PDB id
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2xfq
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Contents |
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* Residue conservation analysis
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PDB id:
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| Name: |
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Oxidoreductase
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Title:
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Rasagiline-inhibited human monoamine oxidase b in complex with 2-(2- benzofuranyl)-2-imidazoline
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Structure:
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Amine oxidase [flavin-containing] b. Chain: a, b. Synonym: monoamine oxidase type b,mao-b. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: maob. Expressed in: komagataella pastoris. Expression_system_taxid: 4922
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Resolution:
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Authors:
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D.Bonivento,E.M.Milczek,G.R.Mcdonald,C.Binda,A.Holt,D.E.Edmondson, A.Mattevi
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Key ref:
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D.Bonivento
et al.
(2010).
Potentiation of ligand binding through cooperative effects in monoamine oxidase B.
J Biol Chem,
285,
36849-36856.
PubMed id:
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Date:
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26-May-10
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Release date:
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06-Oct-10
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PROCHECK
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Headers
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References
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P27338
(AOFB_HUMAN) -
Amine oxidase [flavin-containing] B from Homo sapiens
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Seq:
Struc:
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520 a.a.
499 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class 2:
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E.C.1.4.3.21
- primary-amine oxidase.
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Reaction:
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a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4+
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primary methyl amine
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+
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O2
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+
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H2O
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=
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aldehyde
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+
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H2O2
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+
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NH4(+)
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Enzyme class 3:
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E.C.1.4.3.4
- monoamine oxidase.
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Reaction:
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a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2
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secondary aliphatic amine
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+
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O2
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+
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H2O
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=
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primary amine
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+
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aldehyde
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+
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H2O2
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Cofactor:
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FAD
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FAD
Bound ligand (Het Group name =
FAD)
corresponds exactly
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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J Biol Chem
285:36849-36856
(2010)
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PubMed id:
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Potentiation of ligand binding through cooperative effects in monoamine oxidase B.
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D.Bonivento,
E.M.Milczek,
G.R.McDonald,
C.Binda,
A.Holt,
D.E.Edmondson,
A.Mattevi.
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ABSTRACT
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Links
