PDBsum entry 2eo2

Oxidoreductase

PDB id: 2eo2

Contents

Protein chain

71 a.a. *

* Residue conservation analysis

PDB id:

2eo2

Name:

Oxidoreductase

Title:

Solution structure of the insertion region (510-573) of fthfs domain from mouse methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like protein

Structure:

Adult male hypothalamus cdna, riken full-length enriched library, clone:a230045m11 product:weakly similar to c1- tetrahydrofolate synthase. Chain: a. Fragment: unp residues 510-573. Engineered: yes

Source:

Mus musculus. House mouse. Organism_taxid: 10090. Gene: mthfd1l. Other_details: cell free protein synthesis

NMR struc:

20 models

Authors:

C.Kurosaki,T.Nagashima,M.Yoshida,F.Hayashi,S.Yokoyama,Riken Structural Genomics/proteomics Initiative (Rsgi)

Key ref:

C.Kurosaki et al. Solution structure of the insertion region (510-573) of fthfs domain from mouse methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-Like protein. To be published, .

Date:

28-Mar-07 Release date: 02-Oct-07

Protein chain

Q3V3R1  (C1TM_MOUSE) -  Monofunctional C1-tetrahydrofolate synthase, mitochondrial from Mus musculus

Seq: 977 a.a.

Struc: 71 a.a.*

* PDB and UniProt seqs differ at 7 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.6.3.4.3 - formate--tetrahydrofolate ligase.
• Pathway: Folate Coenzymes
• Reaction: (6S)-5,6,7,8-tetrahydrofolate + formate + ATP = (6R)-10- formyltetrahydrofolate + ADP + phosphate

Molecule diagrams generated from .mol files obtained from the KEGG ftp site